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Soy: natural ingredient of WonderOver

Soy is part of the category to which belong Flavonoids isoflavonoids and phenols that have a form similar to estradiol. Phytoestrogens vegetables contain genistein and daidzein, which possess an action similar to that of estrogen although weaker. Estrogens are provided with an anti-estrogenic action that estrogenic and bind to hormone receptors.

Thanks to their anti-oxidant and anti-estrogenic properties, help to keeping down cholesterol and thus decrease the risk of cardiovascular disease with a preventive action. A good intake of soy alleviates, along with other components such as those contained in WonderOver, the symptoms of menopause including hot flashes.

The phytoestrogens contained in soy also helps in bone mineral density and osteoporosis. Phytoestrogens are present in many vegetables. The natural plant hormones are similar to estradiol, the hormone produced by the ovaries before menopause and taken in appropriate amounts, limit the symptoms of menopause.

Soy is one of the foods with the highest concentration of isoflavones and phytoestrogens. Soy is therefore an excellent ingredient in Wonderup addition to being an amazing food and a great supplement that should be included in our daily diet.

Other features and properties of Soybean

Soy is a food of great value that is getting more and more successful in feeding not only vegetarians but of all the people that care about their health. There are also many supplements soy-based on the market.

Soybeans have a similar flavor to the beans, and can be eaten just like a legume. Are derived from soybeans also many food products present more and more massively on the market not only in stores but also in supermarkets: soybean oil, soy flour, soy sauce (very good condiment used in Chinese cooking instead of salt), soy milk, soy ice cream, tofu (soy cheese), burgers and sausages, meat substitutes for vegetarians. The soybean is in fact composed of 44% protein, much more than the lentils or other legumes.

From the Soy also gives an excellent substance for health: lecithin, a natural emulsifier that keeps in suspension cholesterol in the blood by preventing the formation of deposits on the walls of the arteries. It is excellent for lowering high cholesterol. Cholesterol deposits are a major source of cardiovascular disease. The soy lecithin also enters into the structure of the cell walls by making two of the major antioxidants: vitamin A and phosphorus.

Soy: natural ingredient of WonderOver

Other features and properties of Soybean (Continued ...)

The presence of soy isoflavones makes an excellent help for menopausal problems. Soy isoflavones act like all estrogens balancing both conditions of excess estrogen (such as premenstrual syndrome) that estrogen deficiency (as is the menopause), bringing hormones at proper levels. Isoflavones relieve menopausal symptoms such as hot flashes and thus constitute an excellent alternative to synthetic hormones often used to combat precisely the problems of menopause but with unpleasant side effects which are instead completely absent in phytoestrogens.

Currently, research is indeed investigating two most popular soy phytoestrogens: genistein and daidzein, for their ability to regulate hormonal imbalances. (A. Cassidy et al, Biological Effects of a Diet of Soy Protein Rich in Isoflavones on the mestrual Cicles of Premenopausal Women, in “American Journal of Clinical Nutrition” 60, 1. 994, 333-340).

Some items on the effects and benefits of soy isoflavones in the treatment of menopausal problems
The miracle bean

The Chinese who have regular consumption of soy beans and / or tofu have an incidence of only 50% of cancer of the stomach, colon, breast and lung compared with those Chinese who rarely consume soy or soy products . Soybeans contain fairly high levels of various compounds with proven activities including a high content of isoflavones, such as genistein. These isoflavones have been shown to inhibit the growth of human cells of breast cancer and to the lung.

In addition, a regular use of soy protein (soy beans, tofu, soy beverages, etc..) can lower blood cholesterol and triglyceride levels by 10% to 15%.especially in people with elevated lipid levels .
For many of us the only time that soy got into our diet was when we used salad condiments made with soybean oil. More and more people eat soy beans being aware of the many benefits of this legume. Soybeans are rich in plant hormones, phytoestrogens called isoflavones. These isoflavones are similar in structure to estrogen in the human body, and then add soy to the diet may be a way to increase estrogen levels. At least that is the reasoning behind the interest in soybeans by women approaching menopause.

Soy: natural ingredient of WonderOver

Some items on the effects and benefits of soy isoflavones in the treatment of menopausal problems (Continued ...)
The miracle bean

The observation that the Japanese and Chinese have low incidences of breast cancer, colon and prostate cancer has led researchers to investigate other components of soy that may be beneficial to health. In an article published recently in the Journal of the National Cancer Institute, a laboratory study has shown a compound called genistein as a potential anti-cancer agent in soy.

Genistein appears to affect the metabolism of cancer cells by weakening their defenses against drugs and treatments such as chemotherapy and radiotherapy. Cancer cells have developed enzyme systems to produce protective proteins that allow the cancer to resist treatment.
The genistein seems able to interfere with the production of these protective proteins, thereby reducing the ability of cancer cells to survive and grow. So there may be more than one reason to increase the amount of soy in our diet. It is the protein part that contains genistein, add more soy oil to the salad is not enough.

The TV program on NBC’s “Dateline” on June 9, reported the overall benefits of consuming soy products. One of the topics emphasized in the article was the connection between an increase in the consumption of soy and protective effects against breast cancer. Soy increases production of the hormone dehydroepiandrosterone (DHEA). DHEA is necessary for the growth and development of all tissues and adult tissues require DHEA for proper maintenance.

A subordinate hypothesis of this is that the stability of the cells depends on the DHEA. This has resulted in my explanation of cancer as a result of the reduction of DHEA. The reduction of DHEA may trigger the activation of oncogenes (cancer genes). The DHEA begins to decline after age 20-25, reaching very low levels in old age. The hypothesis is that this is the reason why the incidence of cancer increases with age. Measurable levels of DHEA are reduced in women with breast cancer, and this reduction is about nine years before diagnosis (Geriatrics 1982; 37: 157).

Soy: natural ingredient of WonderOver

Some items on the effects and benefits of soy isoflavones in the treatment of menopausal problems (Continued ...)
The miracle bean

A series of studies demonstrates that treatment with DHEA provides a protective effect against breast cancer. Namely raising DHEA reduces the incidence of breast cancer. A quote also reports the beneficial effects of DHEA in other important areas of older women. “These data show that DHEA has a stimulating action on bone mass and an inhibitory effect on triglycerides, in addition to having a protective effect on the development of mammary carcinoma induced by DMBA in mice. These data suggest that in addition to reducing the risk of breast cancer, replacement therapy of DHEA may also have beneficial effects on lipid metabolism in women who receive this therapy” (Endocrinol. 1997; 138: 3387).

Therefore, increasing DHEA reduces the incidence of breast cancer. A link between consumption of bones, reduction of breast cancer, and increased levels of DHEA sulfate (the precursor of DHEA) was reported in 1995. “There is also evidence that soy products can affect the risk factors for cancer, such as the levels of endogenous hormones. Preliminary data from our group indicate that young Adventist women who are vegetarians with high intake of soy in their diet and a lower risk of breast cancer may have higher levels of an adrenal androgen, dehydroepiandrosterone sulfate” (J. Nutr. 1995; 125 (3 Suppl): 709S-712S).

The show “Dateline” presented the hypothesis that the increase of breast cancer in Japanese women who move to the United States could be a result of a reduction in the consumption of soy than the country of origin. A number of studies have reported the overall benefits of treatment with DHEA in men and women in old age. “DHEA in appropriate replacement doses appears to have remedial effects with respect to its ability to induce an anabolic growth factor increase muscle strength and lean body mass, without significant side effects” (Ann. NY Acad. Sci 1995, 774: 128).

The article of “Dateline” included a discussion with a researcher who suggested many beneficial effects of soy consumption in relation to many diseases. It advances the suggestion that these beneficial effects and the protective effects of soy on breast cancer are the result of increases in DHEA. It is the increase in DHEA which may produce the real beneficial effects.

Soy: natural ingredient of WonderOver

Some items on the effects and benefits of soy isoflavones in the treatment of menopausal problems (Continued ...)
Tofu and other food with a basis soy

In a laboratory study on human cells of breast cancer, high doses of isoflavones - (dietary components that are found in foods made from soy) - have blocking the growth of cancerous cells up to 30%, reported Donna Dixon Shanies, medical and assistant professor of biochemistry and genetics at the New York College of Osteopathic Medicine in Old Westbury, N.Y.

In a second laboratory study, Dr. Shanies has found that traditional Chinese herbal remedies such as ginseng inhibited the growth of human tumor cells of breast cancer.
Because they are loaded with phytoestrogens, isoflavones may help prevent breast cancer by reducing the levels of natural estrogen in the body, says Dr.; also, isoflavones may have antioxidant properties that inhibit the development of tumors.

“Phytoestrogens may in future prove promising agents used to reduce the risk of breast cancer and other hormone-dependent cancers, such as prostate cancer”, said Dr. Shanies.
Even if there are no recommendations on how much soy should be individually included in the diets, the doctor says, “it would be prudent for women to try to eat more soy products”.

Dr. Shanies and colleagues tested the effects of three major isoflavones - biochanin A, daidzein and genistein - on human cells of breast cancers. They also measured the effects of ginseng, hops flower and other Chinese plants on cells of breast cancers.

Calling the new research “a promising first step”, Richard J. Cenedella, Ph.D., chairman of the department of biochemistry at the Kirksville College of Osteopathic Medicine in Kirksville - Mo., Said the findings add a new dimension to what is known about the link between diet and breast cancer. “We’ve always known that there are beneficial effects of a low-fat diet [on the risk of breast cancer], and concentrations of plant hormones in certain foods may play a role in reducing this risk”, said Dr. Cenedella (DM).

Soy: natural ingredient of WonderOver

Soy phytoestrogens: an alternative approach to traditional hormone therapy for menopause?

[Phytoestrogens of Soybeans: An Alternative Approach to Traditional HRT?] - Presented at the “Symposium on the impact on the health of soy protein” - Center for Human Nutrition at UCLA (University of California) January 20, 1998 by Thomas B. Clarkson, D.V.M. Professor of Comparative Medicine at the School of Medicine of Wake Forest University.

The traditional therapy of postmenopausal hormone replacement (HRT) preserves bone density, reduces the risk of coronary heart disease and can sustain cognitive function with the age. Despite these beneficial health effects the use of HRT is low (about 10% of women over 55 years old). This is related primarily to fear of breast cancer and the need for a collateral suministración of progestin.

We focused on the phytoestrogens (genistein and daidzein) from soybeans as potential alternatives to traditional HRT - especially - because they may be protective against breast cancer and are antiestrogens for the endometrium thus obviating the need for a progestin.

Cardioprotective effects

We compared the soy phytoestrogens and conjugated equine estrogens administered to surgically postmenopausal monkeys with their effects on concentrations of plasma lipoproteins. Soy phytoestrogens increased HDL cholesterol and Apo A1 more than conjugated equine estrogens, and LDL cholesterol was decreased more by soybeans.

Conjugated equine estrogen, but not soy phytoestrogens, resulted in hypertriglyceridemia. Data on atherosclerosis in postmenopausal female monkeys are incomplete but both phytoestrogens that conjugated equine estrogens inhibit progression of atherosclerosis. Soy phytoestrogens, such as estradiol, enable the coronary arteries to dilate in response to acetylcholine.

Effects on breast and on endometrium

We compared the effects of soy phytoestrogens and conjugated equine estrogens on breast and uterus in postmenopausal monkeys. Soy phytoestrogens are not estrogen agonist for either breast or to the endometrium; also have estrogen antagonist at these organs preventing the usual proliferative changes induced by estradiol.

Soy: natural ingredient of WonderOver

Effects on the brain

The effect of soy phytoestrogens on brain biomarkers of cognitive (brain derived neurotrophic factor and acetylcholine production) are comparable to those of estradiol (UCLA Center for Human Nutrition 900 Veteran Avenue Los Angeles, CA 90095-174).

Soy Protein Isoflavone Effects on Breast Tissue

Presented at the “Symposium on the impact on the health of soy protein” - Center for Human Nutrition at UCLA (University of California) January 20, 1998 by Stephen Barnes, Ph.D. Professor of Pharmacology and Toxicology and Biochemistry and Molecular Genetics to the School of Medicine at the University of Alabama at Birmingham.

The isoflavones, so abundant in soy, have been proven to have biochemical and biological effects in a series of in vitro and animal models. These effects are not only based on the estrogenic properties of isoflavones, but also their role as inhibitors of protein tyrosine kinase, regulators of gene transcription, modulators of membrane transporters and as antioxidants.

Predicting the outcome of the effects of isoflavone-rich diets, such as those based on soy, on chronic diseases (cancer and heart disease) should not be based on only one of these mechanisms. For example, the prevention of osteoporosis by isoflavones (an estrogenic effect) is in contrast with epidemiological and laboratory data that suggest that soy and isoflavones prevent cancer.

However, the recent discovery of a new estrogen receptor (ERP) which selectively binds the isoflavone genistein provides new arguments to explain the paradox of estrogen. the ERP shows a possible distribution of tissue different from the classical estrogen receptors, being abundant in bones, brain, cardiovascular system, the genitourinary system, lungs and prostate, but not in the breast.

Thus isoflavones may be naturally occurring forms of an important new class of drugs called selective estrogen receptor modulators, currently in development for the treatment of the disease in postmenopausal women (UCLA Center for Human Nutrition 900 Veteran Avenue Los Angeles, CA 90095 More Abstracts - 1742 © Copyright 1998 Indiana Soybean Board).

Soy: natural ingredient of WonderOver

Cancer killer - A hormone in soya beans starves tumour cells to death
New Scientist 14 mar 98

Biochemists in the United States have identified as a key ingredient in soy beans annihilates cancer. They showed that genistein, a plant estrogen, plays a key role in suppres-
sing the growth of cancerous cells. Asian diets high in soy have been linked to a lower incidence of cancer, particularly breast, colon and prostate cancer.

This bond has been reinforced by evidence that when Asians migrate to the U.S. and abandon the soy-rich diet, their risk of developing these cancers increases.
Amy Lee of the University of Southern California in Los Angeles has discovered that genistein is a key factor in this. It works by weakening the cancer cells’ response to the stresses that usually impel them to grow faster. “When a cancer cell growing at full blast, the cells soon run out of oxygen and glucose that are normally supplied by the blood”, says Lee. To compensate, they send out an SOS chemical that unleashes the formation of new vessels to nourish the tumor, a process called angiogenesis.

In previous experiments on tissue cultures, Lee and others have demonstrated that genistein may blunt the response of cancer cells to stress. Now, they know the exact mechanism. She and her colleague Zhou Yanhong have demonstrated that genistein blocks the action of a transcription factor known as the CCAAT binding factor.

This protein normally binds to a genetic “reason” important in DNA and triggers the stress genes. Genistein adds phosphorus to the binding factor, neutralizing it before it is activated, so that cancerous cells die because deprived of their nutrition (Journal of the National Cancer Institute, vol 90, p 381).

“This is preliminary evidence, but genistein really stands out as the ingredient that is most active in blocking cancer growth and angiogenesis”, says Lee. Crucial thing, the researchers found that genistein has no effect on normal, healthy cells that are not rapidly dividing cells such as cancer. “Do not shut off the normal synthesis of this protein in healthy cells”, says Lee (Andy Coghlan).

Soy: natural ingredient of WonderOver

Breast cancer: reduce mortality and soy
Jama 2009;302(22):2437-2443

The introduction in the diet of soy-based foods reduce the risk of recurrences and death in women with breast cancer. The confirmation comes from the Shanghai Breast Cancer Survival Study, a large study published in Jama who has finally made clear on the anticancer properties of isoflavones, a class of phytoestrogens previously subject to dispute.

The research, which was completed in June 2009, provided for the recruitment of more than 5,000 women, aged between 20 and 74 years, which between March 2002 and April 2006 had been diagnosed breast cancer. In summary, high consumption of soy have appeared associated with a lower incidence of mortality and recurrences, compared with the lowest consumption (hazard ratio = 0.71 and 0.68, respectively). In addition, the rate of mortality and recurrences at four years was 10.3% and 7.4% and 11.2% and 8.0% for low and high intakes of soy, respectively.
This inverse correlation is evident for tumors with estrogen receptor-positive and estrogen-negative and is found both in women treated as in those not treated with tamoxifen.