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Serenoa Serrulata Extract

Discovered in 1926, is a plant of the Arecaceae family, only species of the genus Serenoa. In the medical field is known as sabal serrulata and as saw palmetto, the name by which it is commonly known in the United States where it grows, as in southern Europe and North Africa.

This palm produces mono red seed fruit or purple, depending on the maturity and does not exceed 3 meters in height.

The fruits have diuretic, sedative, anti-inflammatory, anti-androgenic, anti-exudative, with both estrogenic and anti estrogenic properties.

The extract derived from the plant is often used for prostate hypertrophy, colds and coughs as an expectorant, but especially in the field trichological as a natural remedy for combating and preventing hair loss.

In fact, the main feature of the extract of Serenoa is to enter into circulation in the conversion of testosterone into DHT (dihydrotestosterone), which takes place thanks to the intervention of the enzyme 5 alpha-reductase.

The interest generated by the studies on saw palmetto is due to the fact that the drugs commonly used to mitigate the effects of alopecia have numerous side effects such as decreased libido and erectile dysfunction that, with a treatment based on natural principles, would not occur.

The application of the extract based on Serenoa as anti fall remedy has no negative side effects instead.

Now the effectiveness of Serenoa repens against baldness is demonstrated by several studies in order to assess the effectiveness and found a significant reduction in loss and a good percentage of regrowth.

The hair loss in men is determined by a genetic predisposition that makes the follicles of hair very sensitive to the level of hormones in the bloodstream and in particular to dihydrotestosterone (DHT), which damages the follicle making atrophic.

The body reacts to this attack of DHT by creating an inflammation mediated by the immune system, and this creates further damage to the follicle that often leads to death.

The extract lipidosterolic of dried fruit of Serenoa inhibits the conversion of testosterone to dihydrotestosterone mediated by the enzyme 5-alpha-reductase.

The effects of Serenoa may be summarized as:

Inhibition of 5-alpha-reductase and the binding of DHT to androgen receptors;

inhibition of the cellular and nuclear androgen receptors;

anti-estrogenic and anti-inflammatory activity;

Generic reduction of edema.

Serenoa repens is a valid approach to treat mild to moderate hair loss and a good alternative for those patients who can not take finasteride or topical therapies. Ultimately Serenoa repens is able to stabilize the baldness without causing side effects.

Saw Palmetto can be used all year in the presence of dandruff and dermatitis, when the hair is without fiber, weak and not very full-bodied. In particular is a valuable ally in the summer, when the hair submit to the dangerous action of the chlorine in swimming pools, of the wind, of the sand and sun; The Serenoa extract strengthens the hair structure and improves the circulation and oxygenation of the scalp, preventing even the copious losses that usually occur in the fall as "relapse" negative of the stress suffered by the hair during the summer.

Serenoa repens is also useful in other androgenic problems like acne and excessive secretion of sebum (oily skin).

The extract of Serenoa repens is the best known among the inhibitors of 5-alpha-reductase on botany origin.

Serenoa repens is composed of phytosterols and flavonoids that have anti-androgenic activity through two mechanisms: the first is a direct action against cytoplasmic receptors of dihydrotestosterone (DHT); the second is an indirect action of inhibition of 5-alpha-reductase of type I and type II.

Serenoa repens also activates the receptors for estrogen. In particular, the phytosterols, beta-sitosterol (present in the plant), with estrogenic activity, can stimulate mitosis of the matrix by activating adenylate cyclase. This helps to maintain the anagen phase and normalize the catagen phase.