Citrus Aurantium

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(E.S. Tit. 6% Synephrine in Reductup Women: dry extract obtained from orange peel)


The citrus aurantium contains the following elements: sympathomimetic amines (synephrine, octopamine) bioflavonoids (neohesperidin, naringin, hesperidin) and flavonoids (tangeretin, nobiletin, sinensetin, auranetina, different routines, etc..), essential oils, bitter substances (auranziamarina) coumarin compounds.


The citrus aurantium is stimulating the adrenergic system and selective beta-3 receptors. Stimulator of gastrointestinal function.

  • Coadjutant in low-calorie therapy
  • Tiredness and exhaustion
  • Anabolic effect
  • Absence of appetite
  • Dyspeptic disorders

The citrus aurantium has a long tradition of use in Chinese medicine, where it is used as a tonic for the body’s vital activities, such as the stimulation of the circulation in congestive respiratory events and the solicitation of efficiency in situations of gastrointestinal indigestion.

The bitter orange or citrus aurantium is composed of two sets of substances: volatile ones, forming the essence and those stable, formed especially from flavonic glycosides (hesperidin and derivatives), pectins (in the mesocarp) and bitter substances of a chemical nature is not defined.
It was discovered that the rind of the fruit, known for itscontent of bioflavonoids, in some moments of maturation, that is when the fruit has not yet reached maturity, is a collection especially rich in adrenergic amines.
Have been identified the five fundamental that are: synephrine, N-metiltiramina, hordenine, octopamine and tyramine, whose stability in the extract phytotherapic is only assured by a careful extraction process.

Recent clinical and scientific studies have proven for these standardized extracts of citrus aurantium thermogenic outcome with a selective increase in metabolic activity of the human body: they facilitate the use of fat to energy, with improvement of physical performance by the method of ’increase in beta-oxidation of fats in the muscle which, in turn, supports the increase in lean body mass.

Synephrine is certainly the most sympathetic-mimetic amine known with thermogenic activity: it has been proven its potential to stimulate the system with selective beta-3 receptors. The beta-3 receptors are the receptors most common compound in adipose and in the liver.
Synephrine originates the release of adrenaline and noradrenaline without interposing on other types of adrenergic receptors (alpha-1 and 2, beta-1 and 2). This task gets a good thermogenic action without secondary consequences.
The consequently effect is a direct solicitation of beta-3 receptors which, in turn, are responsible for the processes oflipolysis of fats present in adipose tissue. At the same time, get an increase in basal metabolism with a consequential increase of the daily caloric consumption.


Although this is a very active plant complex, studies on acute and permanent component of this validate the safety of use of standardized extracts of citrus aurantium, if we adapt strictly to the instructions for use.

The sympathicomimeticmimetic amines contained in the extract are definitely less than that used pharmacological purposes. Do not use in pregnant and lactating women and under 12 years. In the presence of cardiovascular disease and / or hypertension, before taking this product, consult your doctor.

The citrus aurantium directly attacking the fats already deposited, favors their conversion into energy and facilitates their disposal. Ensure a vigorous lipolytic effect (activity in which are break down fats).

The citrus aurantium bitter varieties fruit dried and unripe (orange bitter) contain synephrine itself, sympathicomimetic amine can lead to a significant decrease in food intake and body weight.
The synephrine contained in citrus aurantium has chemical form similar to noradrenaline and sympathicomimetic activity exerts indirect as it reduces, at the synaptic level, the uptake of noradrenaline releasing it more usable.

Among the beneficial results, the most significant decrease in appetite exerted at the level of the CNS and increased lipolysis due to the solicitation receptor beta 3 (thermogenesis).
The thermogenic process is governed by the relationship of norepinephrine receptors with B-adrenergic beta-adrenergic receptor in a complex with the enzyme system denilatociclasi. The activation of the adenilatociclasi, in turn governed by protein-G stimulatory action, increases the dimensions of the intracellular second messenger cyclic AMP (adenosine monophosphate is a metabolite of the cells produced thanks to the enzyme adenylate cyclase from ATP ).


The increase in cyclic AMP provides increased lipolysis and an increased mitochondrial oxygen consumption, an indicator of increased thermogenesis (literally “heat development”). This activity is different from subject to subject as closely related to genetic causes (metabolism) that define the amount of a fabric very particular, said brown adipose tissue.

This tissue, abundant at birth and that decreases with the passage of years, is a metabolically dynamic tissue, generating heat and energy by “burning” the fat to a greater extent than any other area of the body.
The localization of brown adipose tissue is mainly on the trunk and abdomen and breast. The mansion of this fat is to generate power and heat. In infants has the task to balance body temperature.

This activity is called thermogenesis and is actuated also after a meal, thus limiting the impact of the calorie consumption on the weight of the body and on adipose deposits, dissolving the energy derived from food in the form of heat.
In overweight individuals, often the white fat is not capable to perform the utilization of fat as “fuel” for generating heat, with a consequential increase in body weight and adipose tissue.

The white adipose tissue stores, on the contrary, calories in excess, resulting in the increase of body weight. The white adipose tissue develops to a greater extent in the prenatal period and propagates rapidly after birth. It is ubiquitary but is far more present in the abdominal area, pericardium, renal, muscular, breast and skin.
It is the essential forum of the accumulation of triglycerides. The stimulation of thermogenesis in the white fat (rich in beta3 adrenergic receptors) that are driven to behave metabolically as brown fat, is a useful method to limit and control weight, and the results are durable, because the weight loss is due to the elimination of fat and water.

The Italian Ministry of Health allows a maximum dose ofsynephrine of 30 mg. / day as a substance found in supplements. The citrus aurantium is contraindicated for those who suffer from cardiovascular disease and / or hypertension.