Carnitine

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Carnitine: ingredient of Reductup Man

(L-carnitine hydrochloride in Reductup Man (81.55% of carnitine))

Carnitine is an essential molecule for the metabolism of fatty acids. Inside the human body is synthesized in the liver. It is not an essential amino acid and it is generated by the rapid transformation of lysine and methionine.

The carnitine bay to the passage of fatty acids across the membranes of the mitochondria (energy generating locations in all units biological organism), where they are used as energy sources. Carnitine is present to a greater extent in heart and skeletal muscle.

Carnitine is synthesized by humans and other vertebrates from the lysine in the liver and kidneys. The total amount in carnitine is assimilated by man to the extent of 25% for renal and hepatic synthesis rate of 75% absorbed with diet.

Carnitine is a "carrier" of the long-chain fatty acids. In humans, carnitine operates especially in muscle cells, neurons, hepatocytes but also in adipocytes and in more types of tissues.
The L-carnitine, known only as Carnitine is a nutritional supplement, sometimes called vitamin BT, which carries fatty acids into mitochondria, thus promoting the use and disposal of fat in the body.

Originated from amino acids, carnitine may rediscover in practically all body cells and is generated especially in the liver and kidneys. It is a nutrient and its intervention has two main activities: one is the displacement of long-chain fatty acids into mitochondria, the metabolism of which creates natural energy especially in cardiac and skeletal muscle. The other activity is to eliminate the short-chain fatty acids and medium from mitochondria, as would hamper the regular functioning of cells.

The carnitine supports the caloric power supply to the cells, in particular to those of muscle tissue. The cells that suffer from a lack of oxygen or that have deteriorated in some other way, may be in the condition not generate by themselves a satisfactory amount of carnitine. An additional contribution of carnitine supports in particular parts of the body subject to chronic damage.

What occurs throughout the body, in the event of permanent disorders, may occur in single units or in biological tissues subjected to harmful stimuli or to oxygen deficiency. Resul-
ting in this way a lack of carnitine transient and limited locally and makes the cells almost completely unable to defend themselves and can lead them in a vicious cycle caused by a decreased energy supply and a reduced formation of carnitine.

A satisfactory supply of energy has a major influence not only in muscle cells, because significant outcomes of carnitine are also found on brain nerve nucleus, on liver cells and sperm. An appropriate energetic balance allows the cells to remove and destroy foreign substances, to burn fat and make all the physiological activities.

Indications

The carnitine facilitates the conversion of lipids into energy. This activity allows to optimize the conditions and general wellness body, thanks to a more substantial amount of “fuel” can be used. In addition to this, carnitine has antioxidative properties and assists the body to destroy free radicals that cause detriment to the cells and line which are imputable to many diseases and presumably of the aging process. A further interesting side effect ensured by carnitine is the loss of weight, since it converts the fat located in the body in energy.

Cardiovascular disease

Cardiac diseases is the first field use of carnitine. In these diseases are part of the circulatory disturbances of the heart muscle such as angina pectoris and post-infarction conditions, heart failure of any origin and rhythm disorders.
Carnitine improves lipid values in reducing blood cholesterol and triglycerides and increasing the proportion of HDL (also called good cholesterol). This activity provides a protective effect against cardiovascular diseases, as is decreased the risk of calcareous deposits in blood vessels.

Favoring the supply of oxygen to the cells, carnitine implements safeguard action directly on the heart muscle. The optimization of the supply of oxygen is of vital importance for the heart because, being a muscle bound to recurring stimuli, needs a very high dose of oxygen.

Neurological diseases

It is believed that carnitine has a direct influence on acetylcholine, an essential neurotransmitter for many activities of the brain; this activity is conceivable given the similar chemical structure. It is therefore appropriate to give carnitine to patients suffering from Alzheimer’s disease, a disease whose cause is to insufficient acetylcholine. The results obtained after administration of the substance are very promising. Carnitine has provided clear results in both patients at the primary stage of the disease that in individuals afflicted with Alzheimer’s disease for long.

Due to its antioxidant conduct, strengthens brain cells, increases the efficiency and functionality can go almost all the functions of acetylcholine. The administration of carnitine has had good results in older people, even in cases of depression originated in part by modifying the biochemical activities inside the brain.

Carnitine can perform an action of support for further countermeasure in persistent infirmities of different organs, such hepatic cirrhosis. The term diseases of metabolism of sugars and fats represent other therapeutic groups.

Carnitine is also used in sports medicine as a supplement to a competitive level. The L-carnitine is a natural component the cell in which practice a fundamental role in the use of lipid substrates.
It is in fact the only means by usufruibile long-chain fatty acids to cross the mitochondrial inner membrane in order to be addressed towards the beta-oxidation.

In indirect mode, carnitine also influence the glucose metabolism and protidico: the oxidation of fatty acids limits the use of peripheral glucose while permitting the passage of acetyl groups (remaining of beta-oxidation) in the Krebs cycle, consequently increasing the possibility of using energy of the cell.

Decisively has proved the therapeutic use of carnitine in deficiency myopathy by the substance and recently it has been found particularly advantageous to use in cardiac dysfunction. The carnitine plays a fundamental role in the cardiac metabolism because the oxidation of fatty acids is subordinate to the presence of balanced quantities of the substance.

Recent research has proven that in many stress conditions, of acute ischemia, myocarditis of diphtheria can be verified a decrease in myocardial tissue levels of carnitine.
L-carnitine is absorbed at the enteric level and reaches peak blood supply to the third hour; good blood levels are kept for about 9 hours. The elimination takes place through the kidney in unchanged form for over 80% in 24 hours. It is found in all tissues and muscle parenchymal. There are no known carnitine incompatibilities with other medicines.

Side effects, contraindications

At the concentrations indicated, are not known side effects.

Instructions

Before taking dietary supplements is generally advisable to consult a specialist, especially in the presence of chronic diseases and taking regular medication. If disturbances occur, consult informing him of the administration.