How It works

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The anti-diabetic action of Poterium was already known to the inhabitants of the steppes who succeeded, drank the decoction for several months, to reverse the signs and symptoms of diabetes mellitus, while continuing the harmful assimilation of carbohydrates.

One of the first researchers who has attempted to give meaning to peculiarities of the plant was Dr. Aiman Kuzbari Damascus, a physician and pharmacologist, who thought that the hypoglycemic outcome of Poterium spinosum was due to one or more substances present in the root bark main of the plant and capable of favoring endogenous formation of insulin by the pancreatic islets of Langerhans, unlike to oral antidiabetic drug (sulfonilurati), which induce the improvement without curing the disease.

In Italy, the tincture of roots of Poterium spinosum was used for the first time for the cure of diabetes mellitus by Dr. Luigi Oreste Speciani, who worked a dye extracted from plants Poterium Lebanese, who, with the beginning of the war, were no longer obtainable. The plant is also used against gastritis, toothache, gum inflammation and as a sedative. Secondly, the Poterium also serves as a peripheral and coronary vasodilator, anti-hypertension, arrhythmias and anti sudorific.


Hypoglycemic agent type ILA: Insulin-like-activity. Steinmetz said that the Bedouins of every age and certainly with clinically diagnosed diabetes, drinking the extract of the plant, are "cured" of their disease and that "all of the disease symptoms are gone." The author states that the active ingredient of the plant stimulates the islets of Langerhans in the hormonal function. It assumes in fact that the plant, similarly to oral antidiabetic (sulfonilurati), regulate the endogenous production of insulin by the pancreatic Langerhans islands.

A major study by J. Shani, Joseph B. and F.G. Sulman has evidenced the following characteristics of Poterium spinosum:

1)    - Stability of the active ingredient: The active ingredient hypoglycemic agent is unstable in very acidic solutions, while it is stable to heat and cooking. The medicinal activity of the plant root remains even after prolonged cooking.The entire root with bark and stem, the fruits and the thorns have been tried. Only the root bark has proven to have a significant hypoglycemic action

2)    - Chemical structure: the active substance has a very simple chemical structure, plausibly a small molecule or a peptide

3)    - Efficacy in the diabetic only and not in the healthy person. The active ingredient does not reduce significantly the rate of blood glucose in healthy, while has proven its worth in diabetics. Only diabetics fact react

4)    at the Poterium spinosum, while others show no hypoglycaemic reaction.


a) - vasodilator peripheral (from eptaidrossiflavani)

b) - Coronary Vasodilator (from polymerized flavonoids)

c) - antihypertensive (from eptaidrossiflavani)

d) - antiarrhythmic (from eptaidrossiflavani polymerized)

e) - Antidròtic, anti sweating (adiaforètico)

f) - Astringent (as tannins)

g) - Anti neuritic


The Poterium spinosum (L.) is a valid and effective therapeutic aid in the treatment of Type II diabetes as capable significantly moderating blood sugar levels. Such behavior had already been evidenced in the literature and in ethno-medicine. The action of Poterium spinosum also allowed the suspension of oral hypoglycemic agents. In patients with insulin-dependent diabetes, herbal remedy does not appear to be valid in its entirety, although it has allowed a significant decrease in units of insulin in patients who used it for years.

The Poterium spinosum can be prescribed alone or integrated with those therapies that are the classical treatments, first of all insulin which remains the basic plank and often irreplaceable in the forms of severe diabetes. It should be said that in cases where there is a microangiopathy (alteration of the ocular fundus, kidney or nervous system) the cure with Poterium spinosum is an effective and valuable therapeutic aid.

The sulfonylureas prescription is in fact contraindicated in diabetic vascular complications because it seems to increase cardiovascular risk and no study conducted to date has allowed us to demonstrate improvements in outcome for for effect of sulfonylureas. It is also difficult to acquire a safe blood glucose control with sulfonylureas in obese subjects and also the cardiovascular risk in these cases seems to be greater than with diet alone.

Poterium spinosum (L.) is definitely a medicinal plant very promising for its use in clinical practice. Its role in the treatment of type II diabetes mellitus is undoubtedly effective and free of side effects.The absence of toxicity makes the plant particularly suitable to a prescription for long periods of time in patients in whom it is necessary and possible a prolonged stimulation of the endocrine component of the pancreas.

We can assert that the plant is equipped with a surely 'recognized anti-diabetic action, already known for some time and confirmed by several authors.

Its prescription is without doubt essential in all cases of florid insulin-independent diabetes, and become first choice especially when the administration of oral antidiabetic is not recommended for the presence of vascular complications, microangiopathic or neuropathic.

Its efficacy and especially the potential of action in helping a disease so complex, make the Poterium spinosum an important and interesting oral antidiabetic agent.

On the contrary of oral antidiabetic, the Poterium spinosum, thanks to the content in hepta hydroxy flavans and polymerized flavonoids, would be able to counteract and prevent some of microangiopathic complications thanks to the 'action that the substances possess.