Mycream Man - Caffeine

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Caffeine: natural ingredient of Mycream Men

Cosmetic use of caffeine in Mycream Men

Caffeine, in cosmetics, has higher use as an adjuvant for the treatment of the reduction of subcutaneous adipose tissue, given the potentialities lipolytic and thermogenic. The blemish due to the accumulation of fat in subcutaneous adipose tissue is particularly common in women though, albeit to a lesser extent, can also occur in man and is expressed in areas of the body such as thighs, gluteus, hips, breasts.

  • 1) Front range of the m. pectoralis major
  • 2) M. pectoralis major
  • 3) Retro mammary bag
  • 4) Lobe glandular
  • 5) Adipose Tissue Subcutaneous
  • 6) Cooper’s ligament.

The adipose process is originated from modifications in the microcirculation, with increased permeability of capillaries in the dermis and placed in lipodermis, which leave the plasma flowing in abundance in the cell interstices originating edema. The concomitant loss of efficacy of the lymphatic drainage system aggravated this event.

The tension that this agglomeration excess implements cells modifies the functions, with consequent alteration of tissue structures tearing up the adipocyte. The loss of cellular content or a combination with adjacent cells stimulates the defense with consequent the synthesis of collagen fiber that incorporates fat cells in an organized organism and isolated: the adipose tissue lump.

The micronodule so formed, undergoes a process of involution caused by dehydration and by the reduced intake of substrates, with consequent formation of encapsulated areas of greater dimensions, said macronodules.
These structures definitively compromise the diffusion of nutrients and oxygen, causing accumulation of catabolic products and waste that lead to cellular degeneration or sclerosis and premature aging of the tissue.

The etiological causes of the excess adipose tissue are multiple. Certainly involved physiological causes such as connective tissue, the existence of mucopolysaccharides with a tendency to polymerize and a deep propensity to reduce the trophic exchanges, cause of the intoxication and cell decay.
The hormonal activity of estrogens that stimulate water retention and liposintesis and the action of corticosteroids, which are considered likely to occur in the etiopathogenesis of this process, predispose the person in excess adiposity. Genetic factors are also implicated.

Caffeine: natural ingredient of Mycream Men

Why do the caffeine in Mycream for Men

Caffeine is the alkaloid substance contained in coffee beans. It is very similar to theobromine, the alkaloid substance contained in chocolate and theophylline, the alkaloid of tea leaves.
These three alkaloids widespread in the vegetable world, are called xanthines that have a molecular structure derived from xanthine. The term derives from the greek xanthos, which means yellow. Caffeine, theobromine and theophylline are xanthines connected to methyl groups and thus are called methyl-xanthines.

Caffeine is 1,3,7-trimethyl-xanthine, theobromine is 3.7-dimethyl-xanthine, theophylline is 1,3-dimethyl-xanthine. Caffeine is very soluble in water, alcohol, ether and in acetone. It is very soluble in chloroform, ethyl acetate and tetrahydrofuran. In aqueous suspension has a neutral pH, its crystals are white, odorless, with bitter taste and have a melting point between 234 and 239°C.

Absorption, distribution, metabolism and elimination of caffeine

The caffeine is well absorbed orally, with a peak plasma greater after 120 minutes. It is able to distribute quickly on all tissues by crossing the blood brain barrier and the placenta. May be present in breast milk and therefore should be adopted special precautions for use during pregnancy and lactation.

The assumption of 100 mg. of caffeine leads to plasma concentrations between 1.5 and 1.8 mg / ml. The elimination of caffeine from the body is accomplished after hepatic metabolism with production of acid 1-metilurico, 1-7-methylxanthine and metilaxantina. About 10% is always removed by the kidneys as unchanged caffeine.

The more responsible for the metabolism of caffeine is the whole of the enzyme cytochrome P-450 A2 which liver cells are particularly gifted. The half-life of caffeine is 2.5 - 4.5 hours in adults and extends substantially in the newborn baby by reason of his immaturity enzymatic system.

Various reasons may still influence the half-life of the molecule, including the condition of pregnancy. Do not forget, moreover, that the assumption of alcohol or medicines such as contraceptives, cimetidine, allopurinol and disulfiram protrude to extend it, while the smoking shortens as it urges the hepatic metabolism.

Caffeine: natural ingredient of Mycream Men

Activity of caffeine

The effects of caffeine are expressed with CNS stimulant activity, on the cardiovascular system, on the liberation of catecholamines, in the gastric acid synthesis and metabolism in general.
The outcome of caffeine is biologically mediated by cyclic AMP (adenosine 5'-monophosphate) with a combined action on two levels. The first is the increase of the synthesis of cAMP that blocks the inhibitor of the enzyme adenylate-ciclasie converts ATP into cAMP, while the second level slows the breakdown of cAMP, to which caffeine inhibits the phosphodiesterase enzyme, that transforms cAMP to AMP.

In addition to this, caffeine influence the activity of various neurotransmitters such as serotonin, the catecholamines, dopamine and certain amino acids.
The effects on the nervous system are controversial since lower doses of 500 mg. promote pleasurable sensations with an increase of waking state, alertness, concentration and the possibility of improving overall physical and psychological functionality.

Opposite, larger doses promote anxiety, tremors, nausea, agitation, inconstant performance and diuresis. These effects are due to inhibition of benzodiazepine receptors by the caffeine alone, provided with a degree of lipophilicity superior of its metabolic and such as to enable it to pass through the hematoencephalic barrier more easily.

Caffeine determines a contractile effect by acting on skeletal muscle structure promoting the release of Ca2 + in the sarcoplasmic reticulum for mutual influence with the receptors rianodic (RgR1). This conduct is used in the European protocol for the detection of malicious hyperthermia, severe symptomatology pharmacogenetics.

The solicitation of similar receptors (RgR2) in force in cardiac and coincident inhibition of phosphodiesterase, motivate action cardio stimulant that at high doses, however, can cause arrhythmia, tachycardia and ventricular fibrillation.

Caffeine: natural ingredient of Mycream Men

Activity of caffeine 

Caffeine and paraxantina can influence the blood pressure As they can increase the systemic vascular resistance through the block of the adenosine receptors with contractile effect. For every cup of coffee, systolic blood pressure increases of 0.8 mmHg., while the diastolic by 0.5 mmHg.

The caffeine is used against migraine to facilitate the absorption and increase the activity of ergotamine, which induces vasoconstriction and reduced blood flow extracrani-
al, affecting the serotonin receptors.

Another effect of the blocking activity of adenosine is the analgesic effect. Caffeine is able to control the release of mediators pain symptoms caused by adenosine at the level of nerve terminals and is able to activate the pathways of adrenaline that implement suppressive action on the pain and stimulate the nervous system by reducing the affective component in processing stimulation.
Caffeine stimulates acid secretion in the stomach by the action on H2 receptors, and for this reason should be avoided in individuals predisposed to ulcers.

Side effects and contraindications

With regard to the acute toxicity, can be identified in the short term outcomes after assumptions between 1 and 5 g. of caffeinethat could cause plasma concentrations above 80 mg/ml.
Symptoms of intoxication show up with assumptions around 250 mg.while higher doses (650 mg.), cause the syndrome of the “coffeinism”, characterized by anxiety, agitation and sleep disorders in very similar to anxiety stress.

This type of anxious manifestation began attract attention already at concentrations of 30 mg. / Ml. a result of assumptions of 1 g. of caffeine. The continued recruitment of small quantities of caffeine found no toxic effects.
In addition, subjects with overt hypertension have not manifested variations connectable to the use of coffee, or have been found increased danger of myocardial infarction.

Caffeine does not appear affect the course of gestation or birth weight, or induce genetic abnormalities. Situations of chronic toxicity can occur in case of prolonged use of coffee in association with cigarette smoking or alcohol, as these will vary the pharmacokinetics of caffeine. Therefore it is difficult to determine whether the consequences are caused solely by the xanthine base or from other causes.

Caffeine: natural ingredient of Mycream Men

Cosmetic activity of caffeine in Mycream Men

Since the formation of excess fat is related to circulatory problems with leakage of fluid into the interstices and exclusion of adipocytes with blocking metabolic exchanges, it is appropriate to take action through a draining and detoxifying action to dissolve the collagen fibers that inhibit the fat cells.

It is for this reason that it may be useful the cosmetic application of caffeine for its capacity to promote drainage and removal of stagnant fluids, even if the primary action of the molecule is to stimulate the mobility of the fatty acids in adipose tissue.

The adipo-lytic activity is recurrent and cyclical in normal tissue, with a periodicity of approximately fifteen days. It occurs through the interventi-
on of hormones such as glucagon and ATCH that stimulate adenylate cyclase to convert ATP into cAMP which, with hormone-like action, stimulates phosphorylation using the activation of lipase adipo-lytic. This allows the hydrolysis of triglycerides in diglycerides that are in a second time separated into fatty acids and then removed.

Caffeine stimulate the activity of cAMP blocking phosphodiesterase the enzyme that degrades cAMP and prevents lipolysis. The local use of caffeine causes no contraindications, at the present, since the transdermal absorption does not show blood concentrations likely to develop systemic consequences.
The topical use of caffeine in the cosmetics sector is suitable for the treatment of localized adiposities and is motivated to the catabolic effects on the adipocytes.

Caffeine has ideal properties to be assimilated for topical application, thanks to a good “HLB” (Hydrophylic Lipophylic--Balance) that does not permit the propagation through the epidermis.
Different formulations have been developed to further optimize the kinetics of absorption, including additional active ingredients including limonene, or using the inclusion of the caffeine in the liposomes.

Absorption is to bring the amount until the to adipocytes on which exhibits the specific catabolic activities removing themselves from admission in the blood vessels and not leading to peak blood such as to stimulate systemic results.

It is useful to recall that the absorption of active ingredients through the skin is conditioned by the level of hydration as the epidermal lipid component is the main vector for the dissolution of the substances applied.
A change or reduction, in the process wear and tear typical of the dermal absorption can lead to reducing the absorption. For this reason it is appropriate a precautionary nutrition and hydration epithelial products with anti-aging specific for the parts to be treated, in order to optimize the validity of the aesthetic care.

A special new use of caffeine provide the use as a sunscreen for the UVC radiation, thanks to the absorption of the electromagnetic spectrum. Protecting power of these emissions highly energetic, that if perpetrated for a long time can develop neoplasms may be borne by the epidermis, is a factor of current and confirmed interest in order to prevent adverse effects determined by the thinning of the ozone layer.

Also in the prophylaxis optic of effects caused by ultraviolet radiations, studies in vitro have shown that caffeine plays protective action against the UVB rays, reducing the neoplastic potentialities.