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Doses of melatonin based on age
From 40 to 50 years: 3 mg at bedtime
From 50 to 64 years: 3 to 6 mg before going to bed
From 65 to 74 years: 3 to 6 mg at bedtime
Aged 75 years and over: 3 to 6 mg before going to bed.
If your family has had to have been previous cases of seizure to aging, it would be appropriate to begin the replacement therapies of melatonin before the expected age. This could prevent the development of disorders that could be based on genetic inheritance.
The recommended dose for those over thirty years, could be the same as that of people between the ages of 40 and the 44 years. The recommended doses are based on melatonin values prescribed by authorized persons during the aging; values taken from the people
  relating to these age and subsequently aged and on the amount of melatonin useful to restore these values to the levels of early age. Every person is different, not only in regard to the aspect but also through inheritance, to lifestyle, to the predisposition, eating habits and experiences as well as also the circumstances of existence for which the dosages can diversify slightly from person to another.
This does not mean that the doses should be determined from tenths of a milligram, since it is not of critical values. In any case, the normal daily dose should not exceed that which is 3 to 6 milligrams also substantially higher daily doses under no circumstances would cause no harm or side effects.
Melatonin should be taken as soon as it starts to get dark. The best time to take it is from 20 to 40 minutes before bedtime. The pineal melatonin production starts only after receiving a signal from the eye telling you that the intensity of the ambient light is decreased considerably. In the case in which an individual should be subject to changes in work shifts, then it their daily cycle that regulates sleep will determine when to take the melatonin in order to achieve the best results.
To sleep abnormalities:
   Begin with three milligrams of melatonin. If you think you have recovered normal sleep pattern, you must continue to take it for at least another two weeks. This allows to rebalance the internal clock of our body and return to rest on a regular basis without the help of melatonin.
  If disturbed or interrupted sleep:
If you have to wake up repeatedly during the night or wake up very early and you can not go back to bed and to sleep again, start with 3 milligrams of melatonin before going to bed. Keep increasing the dose until you reach the 6-milligram dose per day.
For jet lag:
The jet-lag is usually originated by an interruption of the normal circadian cycle (the cycle that regulates our body during 24 hours a day). This often happens when we travel and are subject to several changes of time zone within a short time. The crew members and people who travel often are subjected to the effects of jet-lag. The travel from west to east are more tiring than from east to west.
Melatonin can help to get used to more quickly and effectively
  on the new time once you arrive at your destination. Take 3 to 6 milligrams at bedtime when you arrive at the new destination. Maintain this dosage for the following three or four nights following until the body is not accustomed and adapted to the new schedule. Once back at home, repeat the procedure in order to rebalance the body's internal clock to the usual schedule. Many people who regularly use melatonin to cope with the jet lag, have claimed of not having been affected by the time zone change.
For the prevention of diseases:
Melatonin is a hormone that fights disease and therefore, as such, can help prevent two of the currently most common disorders such as cancer and cardiac infarction.
If a person thinks he is exposed to one of these diseases, it should begin treatment with melatonin before the norm without prejudice to the approval of your physician. Based on the discoveries of Russel J. Reiter, hold a normal level of melatonin can help prevent the development of carcinogenic processes.
It is thought that maintaining a reasonable level of melatonin may also help defend against certain hereditary predispositions. If you have doubts about it, it would be useful to consult the doctor who will perform a necessary blood test which will examine the level of blood lipids, cholesterol and triglycerides.
  The physician should also check the glucose values in order to understand if the insulin metabolism operates in an efficient manner, as well as the liver enzymes to verify the efficiency of the liver itself.
This blood test is not only a valuable diagnostic tool but also allows the physician to determine whether to start the treatment with melatonin or not. The administration of melatonin helps, restoring and bringing back to normal blood levels of the most important lipid, protein compounds, minerals and vitamins returning them to youthful levels.
To rejuvenate your body and for the preservation of good health
This aspect of the administration of melatonin is expected to be the most interesting for most people because it 'is of great interest not only for individuals that enjoy a good mental and physical condition but also for ill.
The melatonin therapy consists in rebalancing restore the level in individuals that have passed the age 45 and return the same levels as when they were 20 years old.
At twenty the level of melatonin in the blood reaches roughly 125 picograms (125 trillionths of a gram) per day. Then it goes down slowly until it reaches the forty-fifth year of age, a time when there is a drastic drop in melatonin levels.
Reached the age of eighty years, the average level of melatonin is less than half the level of melatonin of twenty years. Sometimes it is so low that it can not even be estimated.
The strategy consists in changing the diagram that drapes down and return the amount of melatonin in the body with the same levels of as a young man taking it in the right dose.