Humor Man - Passionflower

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Passionflower: natural ingredient of Humor

The passion flower (Passiflora incarnata) is given depressive action on the autonomic nervous system (enteric motility, heart rate, etc.) and an outcome similar to that induced by sedative benzodiazepines. Its use became therefore particularly suitable in the forms of anxiety.

Among the active ingredients of passionflower is possible to identify different varieties of compounds such as flavonoids, maltol, alkaloids (harmin, harmine, harmol, harmalol, harmaline) ossicumarine, amino acids, sterols, fatty acids and organic. The harmin is a monoamine oxidase inhibitor.

Pharmacological studies for searches of the features of the plant chemical components , have confirmed its depressive action on the nervous system, heart rate, intestinal motility, etc.), An extension of the period of induced sleep and result anxiolytic, compared with a toxicity totally irrelevant.

The action of passionflower is similar to that of classical anxiolytics such as chloral hydrate and bromides and possesses receptors common to benzodiazepines. The pharmacological characteristics of the plant makes it an essential to facilitate weaning from antidepressants.

Has qualities spasmolytic on smooth musculature. Performs a function antacid in the stomach and thanks to its sedative characteristic on Central Nervous System is used for insomnia caused by the brain excitability. Useful in anxiety cases, hypertension, neurovegetative dysfunction.

Of the passionflower are used summit and the active principles of most interest are represented by flavonoids (schaftoside, iso-
schaftoside, isovitexin-2“- O glucopyranoside, isoorientina-2“-O-glucopyranoside, chrysin etc.).
The titration with methods of mass spectrometry and HPLC (high pressure liquid chromatography) showed a certain mutability in the composition of flavonoids according to the different periods of development of the plant and, consequently, requires standardize properly prepared as in Humor.

Clinical applications

The passionflower is capable of calming activities, sedative, tranquilizing and antispasmodic. Double-blind clinical trials carried out have confirmed the utility of the passion flower, used both distinctly that in synergy with other plants, in the treatment of disorders caused by anxiety.

The passionflower antagonizes the outcome convulsant procured from penta methyl entetrazol and prolongs the sleep produced by sedatives. The flavonoids in this plant are similar in respect of benzodiazepine receptors (agonism mechanism).

Some authors testify a contraindication against pregnant women, due to the fact that the active alkaloids possess important armanyc extent; reality that has been refuted recently. Negative consequences are not known at the recommended doses.