Humor Man-- Biancospino

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The anxiolytic and myo-relaxing action of the hawthorn (Crataegus oxycantha L.) is found with a particular conduct at the nervous system excitability. The active ingredients in the plant attenuate insomnia and the sense of anxiety and dizziness.
Hawthorn is well accepted by the body and does not show any secondary outcome. It is rich in flavonoids, which are about 2% of the weight of the dry plant and proantocianidoli, 3% of the weight of the dry plant. This bush has a strong affinity towards the heart, especially due to flavonoids and proantocianidoli.

It is often used to moderate symptoms tachicardici derived from conditions of high stress. It has also an appreciable anxiolytic behavior in the central area, particularly viable in people very excitable in which limits the hypersensitivity, the condition of nervousness and makes them better sleep.
This finding seems likely to be attributed especially to the tannins and flavonoids present in this plant since it has been proven that these procure sedation and enhance sleep.

Decidedly important is the possibility that the hawthorn can to block free radicals. Thanks to its action, the oxidation of LDL, which are the particles of cholesterol that are usual placed in the wall of blood vessels following their oxidation, is greatly diminished.

Hawthorn belongs to the Rosaceae family of which is used the flowering tops and leaves. The active ingredients are especially flavonoids (hyperoside, vitexin-2”-ramnoside), glicosilflavons, procyanidins, pentacyclic triterpenes (ursolic acid,crategolic acid, oleanolic acid, acid acantolic acid neo-tegolic). The title of flavonoids in percentage of drugs should be at least 0.7% (in Humor is 1%).


One of the properties most used of the hawthorn is the moderate sedation, as documented by several studies. Research conducted using the placebo also gave evidence of the validity of the hawthorn in the form of anxiety disorders (associated with Valerian and Passionflower). It is useful to know that hawthorn also has more valuable properties as cardiotonic and anti hypertensive.

This drug shows indeed to be an appreciable vasodilator and is provided with positive inotropic activity and negative batmotropa. Clinical trials have documented the effect in patients with mild conformations of heart failure (NYHA class I-II), especially in those with weak rhythm disorders. The properties are conducted by a positive inotropic effect on cardiomyocytes, increasing the extension of the contraction, with a lower power consumption.


The batmotrop action negative was analyzed by the finding that the intake of preparations of hawthorn increase the absolute refractory period, which defends the myocardium by the appearance of arrhythmias, as can occur with different drugs.

Multiple research (including some with placebo) have assessed the effective-
ness of hawthorn in the improvement of hemodynamic conditions in patients with mild, moderate symptoms of hypertension and coronary artery disease.

The outcome sedative can be used in combination with other products. They are was also highlighted lipid-lowering and anti-atherosclerotic properties of the hawthorn. This behavior is then examined on the possibility of obtain active ingredients to prevent the birth of atherosclerotic plaques in an experimental sclerotic scheme.


It is a plant rich in flavonoids, which may represent about 2% of the dry weight of the plant. Are equally Copious the proantocianidoli, who are able to contribute up to 3% of the weight of the dried plant. The main ones are the hyperoside, the spireoside, the rutoside and quercetin. Are also present mono-C-glycosides of flavones, in particular vitexin, Orienti-
na and 2-ramnosil vitexin. They are also applicable penta cyclic triterpene acids and in particular ursolic acid and oleanolic crategolico aromatic amino acids and amines cardiotonic.

Hawthorn is a plant that is used as a medicament for a long time for its proven actions cardioactive and calming. Indeed, the behavior of the nervous system is not derived from direct events but as a consequence of the normalizing work of heart rhythm, given that the plant would facilitate the overcoming of cardiovascular signals of ’anxiety, rather than owning their own conduct sedative on neuronal circuits.

As far has relevance to the character of cardiovascular events after the intake of hawthorn, they all seem to be validated by studies aimed in this direction with findings in the increase of coronary blood flow to coronary vasodilation, dromotropic positive action, positive inotropic and negative batmotropic. There is also a moderate lipid-lowering and anti-atherosclerotic action and also action “scavenger” antioxidant.

The medicinal functions are to be contributed to the flavonoids (hyperoside, vitexin) and oligomers procyanidinic present in fruits and leaves, however, are not the active ingredient of hawthorn. The process of ’intervention is controversial and has become a case of blocking of c-AMP-phosphodiesterase (M Rossi, 1992; Schussler M et al, 1995), although most current observations do not appear to attest to (Muller A et al, 1999). A functional process reliable, could be the inhibition of the angiotensin-converting enzyme (ACE) or an interruption of the potassium channels.


Cardiovascular function - The hawthorn has a remarkable relevance in regards of the heart, particularly connected to the flavonoids and proantocianidoli. Determines vasodilati-
on of blood vessels and abdominal coronary especially those that carry blood to the heart muscle, it is caused by the release of fibrocells of the muscles of the blood vessel wall, with increase of the blood flow in these areas of the body. Decreases in heart rate and significantly increases the action of digitalis on the heart muscle.


Beyond that flavonoids determine an expansion of blood vessels, which causes a lowering of blood pressure. Hawthorn is therefore very useful to combat angina pectoris, in the neuroses of the heart, in the conditions of hyperexcitability with decompensation and high blood pressure especially if of nervous derivation.

Recently, several studies have been performed and tested clinically in patients with moderate heart failure, who have demonstrated that the dry extract of hawthorn as that contained in Humor can effectively moderate heart rate, swelling of the ankles and blood pressure also manifesting action to strengthen of the contractile ability of the heart and a considerable decrease in the symptoms that afflict these individuals, without the occurrence of any negative collateral consequence.

Sedative action - Hawthorn also has an appreciable sedative action at the central level, particularly effective in patients who are very nervous, in which decreases the emotion, the state of agitation and makes it better sleep. These anxiolytic capabilities are especially highlighted by tannins and flavonoids in force in this plant, because it has been shown that they induce sedation and increase the sleep induced by barbiturates, although it was not fully explained the pattern of action that would favor these beneficial effects towards the central nervous system..

A role in this sense could have also flavonoids, in particular glucosides of apigenol, as it has recently been demonstra-
ted that some of them, such apigenol and chrysin, may undertake activities benzodiazepine with anticonvulsant effects, anxiolytics and hypnotics moderately, since would be able from binding to benzodiazepine receptors both centrally that peripheral.

Anti-radical action - Decidedly important is the ability of the active principles of Hawthorn of allowing the body to capture free radicals and to limit the oxidation of the particles of cholesterol that seek to attach to the wall of blood vessels after undergoing the ’oxidation. This procedure prevents one of the episodes required for the establishment of atherosclerotic plaques in the blood vessels.

Main indications - Increased heart rate over the normal value, mild heart failure or content, mild hypertension, adjuvant in ischemic heart disease.

Side Effects - In special cases can procure upset stomach, particularly in patients with gastritis and / or peptic ulcer, reversible upon discontinuation of therapy.

Contraindications - Should be used with caution in patients with overt bradycardia (heart rate below 60 beats per minute) or disorders of the propagation of electrical impulses in the heart.

Drug Interactions - Increases the ’effect of digitalis on the heart muscle and increases the hypotensive action of beta blockers and other medicinal products with this activity.

Toxicological Data - No harmful consequence has been detected following the administration by mouth of a quantity equal to 30, 90 or 300 mg. per kg. weight per day for 26 days.