Humor against insomnia composition - Passionflower

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To the passionflower (Passiflora incarnata) is given depressive action on ’the autonomic nervous system (enteric motility, heart rate, etc.). And a sedative outcome similar to that induced by benzodiazepines. Its use becomes therefore particularly suitable for different forms of anxiety.

Among the active ingredients of passionflower one can identify several varieties of compounds such as flavonoids, maltol, alkaloids (harman, harmine, harmol, harmalol, harmaline) ossicumarine, amino acids, sterols, fatty acids and organic. The harman shows as a monoamine oxidase inhibitor.

Pharmacological experiments for research of the characteristics of the main chemical components of the plant, have confirmed its depressant action on the autonomic nervous system (heart rate, intestinal motility, etc.). An extension of the period of induced sleep and anxiolytic outcomes with a toxicity totally irrelevant.

The action of passiflora is similar to that of classical anxiolytics such as chloral hydrate and bromides and possesses receptors common to benzodiazepines. The pharmacological characteristics of the grass indicate as essential to facilitate weaning from antidepressants.

It possesses spasmolytic action on smooth muscle. Performs a function anti-acid in the stomach and thanks to its characteristic sedative effect on the central nervous system is used in insomnia caused by brain excitability. Useful in case of anxiety, hypertension, neurovegetative dystonia.

Of the passionflower are using the top and the active principles of most interest are represented by flavonoids (schaftoside, isoschaftoside, isovitexin-2”-O-glucopyranoside, isoorientina-2”-O-glucopyranoside, chrysin etc.).
The titration with methods of mass spectrophotometry and HPLC (high pressure liquid chromatography) showed a certain mutability in the composition of the flavonoids according to the different periods of the development of the plant and consequently is necessary to standardize properly the prepared as in Humor.


The passion flower is capable of calming activities, sedative and antispasmodic. Double-blind clinical trials carried out have validated the usefulness of the passion flower, used both separately and in synergy with other plants in the treatment of disorders caused by anxiety.

The Passionflower antagonizes the convulsant outcome procured from penta-methyl-entetrazol and extends the sleep produced by the sedative. The flavonoids in this plant are similar with regard to benzodiazepine receptors (agonism mechanism).

Some authors testify a contraindication for pregnant women, due to the fact that the active ingredients include harmanic alkaloids in important measure; reality that has been repudiated recently. There are no known adverse effects at the recommended doses.