Humor against insomnia - St. John’s Wort.

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St. John’s Wort (Hypericum perforatum) acts synergistically on depression through various processes such as blocking monoamine oxidase type A (MAO-A) and catechol - metiltransferasi (COMT), which implies an increased activity of the nervous mediators having a stimulating action. Both of these actions are due to quercetin, its aglycone altetraidroxantone producing a marked antidepressant effect.

St. John’s Wort may act against premature ejaculation due to the possibility that its active ingredients have to inhibit the reuptake of serotonin, norepinephrine and GABA at the synaptic level.
It is also now established that the prolonged presence of these mediators at the synaptic level is expressed with a strong antidepressant activity. The hypericin can also resettle in the serotonin receptor sites on the nervous nucleus covering the role, even in this situation, of antidepressant.

Hypericum perforatum L. is a herb which are used flowering tops, it is equipped with antidepressant and mood stabilizer. The active ingredients are compounds derived from naphtho diantronics called “hypericin” which include hypericin, pseudohypericin, the cycle pseudohypericin, the isoipericina, the protoipericina.
Are also present flavonoid glycosides, bi flavones, procyanidins felil propanes (in small quantities), acyl flora glucianols hyperforin.


The antidepressant action of hyperi-
cum has been confirmed by multiple tests carried out by comparison with both placebo and with antidepressants known as sertraline, fluoxetine and the laparoxetine.
The results were so encouraging that in Germany, St. John’s wort has been approved by the pharmacopoeia as a method of treatment of anxiety and depression.

The effectiveness of hypericum is comparable to that of the imipramine emaprotiline. It was performed a meta-analysis of 23 randomized trials with hypericum which involved a total of 1757 patients with mild to moderate depression.
The conclusion was that the hypericum extract, assessed after 2-4 weeks is superior to placebo and as effective as traditional antidepressants.

The mechanism of action of Hypericum perforatum is that of inhibition of the reuptake of serotonin in the post-synaptic inhibition of the uptake of norepinephrine and dopamine and bond (in vitro) with the GABA receptor (GABA is the gama amino butyric acid and is an inhibitory neurotransmitter).



At therapeutic doses there is no inhibition of MAO (Inhibitors of Mono-Amino-Oxidase, raise the plasma levels of serotonin, norepinephrine and dopamine by inhibiting the mono-amino-oxidase enzymes that reduce, through a process of oxidation, the concentration hematic of these neurotransmitters), even if the hypericin in vitro inhibits them.

It is reported by some authors a certain hypotensive action. Not recommended for use during pregnancy, in the absence of specific studies. is possible photosensitivity and interference with antiretroviral drugs for HIV.
St. John’s Wort can interfere with the metabolism of carbamazepine, quinidine, calcium channel blockers, losartan, steroids, tamoxifen, taxol, digoxin, theophylline, cyclosporine cliclo, estroprogestinics, warfarin, fenitorina, tolbutamide, digoxin.


In particular, it determines a discrete increase in nocturnal production of melatonin. This action promotes restful sleep and a better awakening without disturbing the sleep REM (rapid eye movement is the “rapid eye movement” that takes place during one stage of sleep during which occurs the re processing and storing of the events of the day).


The extract of St. John’s wort reduces the formation of interleukin-6 capable of sustaining the release of corticotropin reason often connected to depressive manifestations. Outcome calming nervous anxiety and relaxation placed in relation to the intervention of bioflavonoids, hyperforin, procyanidins.