Humor against anxiety and depression - Valerian

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Valerian: natural ingredient of Humor

Side effects

Preclinical studies have shown low toxicity of the extracts of the roots of Valeriana officinalis, both in acute both in repeated doses, for a period of 4-8 weeks. In humans, undesired outcomes caused by Valeriana officinalis seem really rare and the U.S. Food and Drug Administration considers “GRAS” (Generally Recognized As Safe) and generally safe.


Taking into consideration the experimental results, it appears that Valeriana officinalis may potentially give additional outcomes to benzodiazepines. Although there are no direct retries established, Valerian can interact with alcohol, antidepressants and codeine (increasing somnolence). Valeriana officinalis prolongs and increases the sleep provoked by sedatives and therefore should not be used especially in the days before surgical operations that require their use. Similarly of all herbs which include tannins, the assumption of Valerian in conjunction with iron supplementation, may limit the ’assimilation of the latter; It is suggested that separate the two assumptions of an hour or two at least.

Clinical uses

Numerous studies have validated the results of the sedative and spasmolytic active ingredients of the plant, mainly attributed to the valerenic acids. Were examined, in addition, reliance between GABA (an inhibitory neurotransmitter essential for stress) and valerenic acids, despite these ingredients cannot, by themselves, to confuse the benzodiazepi-
nes in the CNS (Central Nervous System) and for this reason their mechanism of action remains largely unknown, if is omitted one of their conformity to the receptors of adenosine, which is provided of values inhibitory on the CNS.

Studies carried out on samples of many patients, many of whom double-blind, have shown a remarkable validity of the essences of valerian, showing a significant decrease in sleep latency without interference on the quality of the same (oneiric activity regular, without modifications of brain activity recordable with EEG).

Valerian does not appear to affect the visual activity or attention due to drive a car or operate machinery, or create synergistic activity to alcohol as developer depression consequences. The toxicity is decidedly low and safety of use considerable.

Contraindications and warnings

Valeriana officinalis is not recommended in children under the age of 12 years.
Valeriana officinalis is unsuitable if you are pregnant, since the results of all laboratory used today are insufficient and do not all have provided clear answers. As a precaution, given the lack of clinical trials explanatory, Valeriana officinalis is also not recommended during lactation.

For any negative consequences at the hepatic level, Valerian is unsuitable in patients with previous or current hepatic problems, and in patients with renal complications. Valeriana officinalis is unsuitable in individuals with allergy to plants belonging to to the family of Valeranaceae.
Your doctor should always be consulted before taking Valerian if is force one of the following conditions:

  • Taking other sedative-hypnotic substances
  • Taking antiepileptic medicines
  • Prior to surgical intervention which presumes the use of anesthesia with barbiturates
  • Real or presumed pregnancy (even if you are planning to conceive)
  • Lactation.