Genesis-Polygonum Cuspidatum

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Polygonum cuspidatum:ingredient of Genesis


Therapeutic indications of Polygonum cuspidatum


Currently, this plant has assumed considerable importance in relation to the high concentration of resveretrol in its rhizomes. The characteristic of the dry extract of the root of the plant is in the resveretrol content that is 400 times greater than grapes and its derivatives. The Polygonum cuspidatum is the largest natural source of this phyto component, which contains in itself the most active biological form.

A further benefit in the assumptionof the Polygonum cuspidatum consists in using a natural extract that in addition to the quality of resveretrol, allows to exploit the benefits of the other active ingredients which complete the functional activity of the extract, as well as support their bioavailability.

Resveratrol is a natural phytoalexin; the fitoalexine are antimicrobial substances produced by the plant as a result of stimuli of various kinds, including the attack of pathogens. Resveratrol is also known as 3,4,5 and 3,4,5 trihydroxystilbene stilbenetriolo, and can have both stereoisomeric forms, cis and trans.

Resveratrol has several activities that may account for its possible cardioprotective activity. Among these it is included the inhibition of the oxidation of low density lipoproteins (LDL), inhibition of the proliferation of smooth muscle cells (up to 70-90% in a dose dependent manner) and inhibition of platelet aggregation. It is recalled that one of the commonly accepted mechanisms for the formation of atherosclerotic lesions is one that begins with the oxidation of low density lipoproteins, rich in cholesterol. The oxidation of lipids facilitates the penetration inside the arterial walls.


Lately it has been documented that resveratrol is a sirtuin activator. The sirtuins are a class of NAD dependent deacetylase responsible for the response to the deterioration of the DNA, involved in the modulation of transcriptional silencing of genes in aging processes and cellular preservation. A large number of sirtuins seem to be interested in promoting longevity in mammals. The resveratrol activates the human sirtuin 1 (SIRT 1), SIR homolog 2 (Silencing Information Regulator) yeast.


Sirtuins specifically induce cell autophagy process that allows cells to convert its own content and selectively remove damaged mitochondria and other organisms. In addition to this SIRT 1 is interested in a plurality of cellular and metabolic events with a decisive role in many of them.
For example, it mobilizes fat from adipose tissue by blocking the activity of PPAR receptors (peroxisome proliferatoractivated receptor-gamma) by its interaction with the nuclear receptor corepressor of NCOR. Moreover, it represses the transcriptional activity of nuclear factor NF-kappa B de acetylating the p65 subunit. SIRT 1 also modulates mitochondrial cell metabolism due to deacetylation operated on the co-activator of PPAR-gamma receptor, PGC1alpha and cell survival under stress by interacting with the FOXO proteins.
Resveratrol is a phytoalexin generated by plants for protective purposes that defends the same from environmental issues such as viruses, bacteria and fungi, in particular Botrytis cinerea, UV radiation, water stress, etc..
It is valid in many human pathologies. Resveratrol leads several well tested on humans beneficial actions and among the most studied there is an important antioxidant activity, common to the chemical class of polyphenols which it belongs.
To resveratrol the scholars confer high anti-aging activities that allow to slow aging and the manifestation of traits typical of aging in vertebrates short lived. This significant biological activity can relate with different biological mechanisms belonging to resveratrol.
Among the most important scientifically proven biological activity of resveratrol on prevention of aging (aging), have antioxidant, anti-inflammatory, vessel / endothelium protective and sirtuino-stimulants.
Resveratrol is particularly studied for its anti-aging activity on the dermis because the skin tissue depicts the first visible manifestation of the body's aging process with the appearance of wrinkles, skin dryness, etc..
Resveratrol is active on cutaneous pathologies at multifactorial etiology, especially if present an inflammatory component, for its ability to inhibit lipid peroxidation, of chelating metal ions and act as radical scavenger. In addition, resveratrol is known to be involved in cellular metabolic episodes like eicosanoid synthesis and lipid metabolism and finally proved to have activity anti-inflammatory, vasorelaxing, anti-proliferative and estrogen. The extract of the root of Polygonum cuspidatum is suitable for the treatment of:
Prevention of cardiovascular diseases
Hypercholesterolemia (excess cholesterol in the blood)
Hyperlipemia (elevated plasma lipoprotein rates)
Prevention of cancer
Gastrointestinal disorders.

The main constituent bioactive in the extract derived from dried root of Polygonum is resveretrol. It a phenolic derivative responsible for many therapeutic properties that are able to perform antioxidant and cardioprotective activity. The biological activity of the resveretrol is supported and increased by the presence of further components present in the Polygonum cuspidatum as the emodin and polydatin.

In recent decades the rise in average life and the maximum duration have prompted a special attention in the study of aging processes. Among the possible actions to improve the length and quality of life, the use of antioxidant substances such as resveratrol could be a winning method.
Resveratrol is a natural phytoalexin synthesized in response to fungal or abiotic agents attacks such as exposure to ultraviolet rays. This polyphenol is extracted mainly from Polygonum cuspidatum, a plant that already the ancients knew and they used for its properties. This plant has now become very relevant and studied, since it was found that its roots contain a high concentration of resveratrol.
Beyond that, it is a component of Ko-jo-kon, an oriental medicine used just to treat cardio-vascular and liver diseases. Resveratrol, like many phytoalexins, possesses a large biological profile and prevents lipid peroxidation and platelet aggregation, change lipid metabolism, promotes anti-inflammatory and vaso-relaxing activity, limiting the damage caused by free radicals and is an agonist of receptors estrogen.
In the last ten years it has been documented that resveratrol, flavonoids (ginesteina, quercetin) and other polyphenols induce apoptosis in cancer cells. In addition, various studies show that resveratrol is able to activate sirtuins, protein compounds desacetyl asici involved in cellular aging and in the induction of senescence.
Antioxidant properties able to perform a protective action of the cardiovascular system. Anti-thrombotic function: limiting platelet aggregation to work on the synthesis of eicosanoids (derivatives of fatty acids) and modulation of arachidonic acid metabolism.
Estrogen-like action (phyto estrogenic): the resveretrol is equipped with a chemical structure similar to diethylstilbestrol, an estrogen-like action to synthetic molecule. Similarly, the resveretrol is in the condition to enable competitive mode with the estrogen receptors. Given that the action associated with this hormone provides for the influence on cholesterol levels and the blood flow, this alternative action mechanism may be used in the prevention of cardiovascular diseases.
Reduction in blood pressure. The resveretrolo induces vasodilation to hypotensive action and intervention on nitric oxide metabolism.
Decrease in triglycerides colesteroloe rates. The resveretrolo protects LDL (low-density lipoprotein, responsible for transporting cholesterol to the body's cells) by the oxidative process which degrades. Lowers total cholesterol and reduces circulating fats. In particular, is noted a lowering of blood levels of VLDL involved in the onset of the 'arteriosclerosis (hardening of the arterial wall tissue).
Resveratrol exerts anti-inflammatory action.
The resveretrol content in Polygonum cuspidatum helps prevent carrying antineoplastic activity; shows an action antioxidant and anti-mutagenic.
It regulates mitogenesis and inhibit a specific tyrosine kinase, an enzyme that acts in the cell signal transduction (conducted antiproliferative, inhibitory in advancing and tumor progression)
It appears to inhibit the onset, promotion and progression of some types of cancer (prostate, colon)
Powerful antioxidant action.
The WHO indicates that the activity of resveratrol is able to reduce the cardiovascular risks of the 40%. Resveratrol is more active than vitamin E. It implements a defense against a wider range of free radicals. It prevents oxidation of low-density lipoprotein (LDL, or bad cholesterol). Limiting platelet aggregation by blocking the action of thrombin and several other aggregating factors.
It promotes the formation of nitric oxide which relaxes and dilates the arteries
It promotes the formation of nitric oxide which relaxes and dilates the arteries
Brain health.
There are some studies that suggest that resveratrol protects the brain from oxidative stress. It is known that oxidative stress is the main cause of most neurodegenerative diseases.
The Polygonum cuspidatum is a concentrated source of emodin (a derivative anthraquinone) and for that the extract of the plant root is used as a nutritional supplement for a regular intestinal motility. In addition to laxative properties, the emodin also have the following effects:
antineoplastic activity
antimutagenic activities
anti-inflammatory activity.
Slows platelet aggregation
It protects myocardial cells by the reduction of oxygen and glucose
Taking Polygonum cuspidatum also causes other effects:
It stimulates the immune system and increases the production of interleukin 2 (promotes the differentiation of T-lymphocytes) and antibodies
It protects the gastric mucosa
It favors antipyretic action
It plays an analgesic effect.