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Feverfew: natural ingredient of E > Micra

Chemical composition

The most important active principles are sesquiterpene lactones called parthenoli-
des. The strong aroma of the plant comes from an essential oil rich in camphor. Contains in itself also a fair amount of flavonoids and sequiterpenic lactones (parthenolide, germacranolide); guaianoli-
di; monotepenici essential oils (camphor); flavonoids (apigenin derivatives) polyacetylene derivatives.

Part used

The flowers and aerial parts of the plant

Pharmaceutical preparations recommended

Dry pulverized and titled in parthenolide min. 0.5% - in E > Micra 1% (British Herbal Pharmacopoeia, 1990), whose daily dose is 6 to 7 mg. per kg. of body weight, distributed in two distributions better if far from meals.

therapeutic properties

Acts in opposition to the headache; the dry extract of tansy as that contained in E> Micra, has proven to block the formation of substances furthering the inflammatory manifestations such as, for example, leukotriene B4, thromboxane B2 and some interleukins.

This occurs because the plant extract prevents the activity of various protein compounds that are responsible for synthesis of the substances mentioned above. Besides that this plant gave way to prove to be able to significantly reduce the production of serotonin, which is a substance able to accommodate the formation of crisis of headache by means the thrombocytes.

These events are mainly due to parthenolides. Was performed a clinical study on 72 patients with cephalic frequent crises. They were divided into two groups, where those who were in the first group were taking one tablet containing 82 mg per day. of dry extract of tansy and those who were belonging to the other a placebo for 4 months.

The same patients would compile a diary where they were to make a note of frequency, time course and intensity of the attacks. The results put in evidence that was detected a 24% decrease in the amount and intensity of the crisis of headache patients in the group treated with the extract of tansy respect of the controls but the course of the attacks was not significantly changed.

It was also detected a decrease in the crisis of retching often associated with attacks of headache. The days of work lost by reason of the crisis of headache in the group taking the extract were 68 compared to 76 in the group with fake medication. There were no side effects worth mentioning. It must be said that the function of tansy is of type substantially preventive, especially in vasomotor headache type.

Feverfew: natural ingredient of E > Micra

Antiallergic action

It has been proven that the dry extract titrated of tansy cause the inhibition of histamine production by biological units capable of this function, referred to as mast cells. Because histamine is one of the most important substances that cause allergy a decrease certainly has beneficial effects on the disease.

Essential information

Cefalea, particolarmente a fine preventivo.

Headache, particularly as prevention

Anti headache.

Side effects

May cause adverse responses epidermal also generalized and irritant dermatitis, but they decay quickly with the ’cessation of therapy.


Given the lack of detailed writings about the effects of extract of this plant on the fetus, its use is not recommended during pregnancy and lactation and in children under 10 years of age.

Pharmacological activity

Also known as feverfew, tansy or feverfew is a plant used in folk medicine as a tonic, peptic and against cramps but also known to resolve fever, articular pain, digestive disorders, gynecological disorders and enteric parasites.

The freshly picked grass was even used to cleanse wounds and bruises as a disinfectant and as a mouthwash after dental extractions.

The etymology of the name is singular: the term feverfew comes from the greek “Parthénion” virgin, to identify its use in gynecological affections; the word type tansy, comes from “anthanasis” expressing “immortality” in connection to the durability of flowering and also the Anglo-Saxon word feverfew is derived from the Latin “febrifuge” to specify its’ use in febrile affections.

Since ancient times has been used in the treatment of migraine, indicating that the current phytotherapy said as predominant in the plant. Clinical trials have indeed demonstrated the usefulness of the plant complex in the prevention of migraines.

The sequi terpenes and especially parthenolide, is considered to be the active ingredient responsible for this action. The procedure up to now substantiated is the interference of parthenolide with the arachidonic acid cascade and in particular the inhibition of prostaglandin synthesis mediated by an inhibitor outcome on the phospholipase A2.

The conduct of the antiphlogistic parthenolide is deemed to be involved also an interference with the enzymes 5-lipoxygenase and cyclooxygenase activation and nitric oxide synthase. The laboriousness of action has made right and proper additional insights that are currently in progress.

Parthenolide has, indeed, manifested to also prevent the platelet aggregation and the release of serotonin in several pharmacological applications.
The indication of the tansy plant complex in migraine prophylaxis is now officially accepted by specific assays ESCOP (1996).

There are no known secondary consequences for long-term use and are not known an interaction with drugs with the exception of a possible interference with anticoagulants. Do not take during pregnancy and lactation.