How It Works

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How does Humor against nervous hunger

Humor activates an intense specific action on serotonergic complex. With this activity Humour does not seem different from many other substances present in nature or not. Vegetable active principles in Humor raise serotonin levels inducing satiety. Humor contains: Hypericum, Passiflora, Chamomile, Valerian, Escolzia and Hawthorn.

All active substances operating on the serotonergic system (chemicals, Passion Flower, St. John's Wort, etc.). they stimulate an increase in the proportion of serotonin in the synaptic spaces between. The accumulation of serotonin is responsible for the side effects of these substances, because it works on the serotonin receptor activating different objectives of various functions.

Humor contains vegetable active principles that selectively they stimulate the 5-HT2C receptors and 5-HT1A receptor. The action on the serotonergic system in this manner is much more effective and selective. The 5-HT2C receptors have the characteristic of being able to regulate our senses of hunger and satiety, while the 5-HT1A receptors are directly involved in mood control.

The natural compounds found in Humor lead to a strong antioxidant action to the cellular mitochondria, and this behavior is responsible for the neuropro-
tective effect of natural active ingredients present in the product “natural supplement” with an innovative method of action which finds its main applications like:

  • Adjuvant weight loss diets to take away the sense of hunger and in particular the bulimic attack (mediated by 5-HT2C receptors)
  • Particularly appropriate in the treatment of overweight in association with diets calories from 1200-1400
  • Assists in the treatment of mood disorders in order to facilitate the disposal of the physiological stress, avoiding the manifestation of anxious states.

See also the Naturdieta Kalospeed product of whose possible association with Humor produces truly amazing results..

Humor is acting on serotonin

Serotonin or 5-HT (5-hydroxytryptamine) is a central neurotransmitter. A important activity of serotonin is to communicate to the brain when the body has taken enough food, given that it is a fundamental part of the “mechanism of satiety”. Serotonin is synthesized in the body by hydroxylation (formation of 5-hydroxytryptophan) and subsequent decarbo-
xylation due to amino acid tryptophan.
Recent studies have documented that amino acids can be used in different processes to control the appetite and to evaluate the nutrients.

How does Humor against nervous hunger

The tryptophane

Tryptophan is an essential amino acid needed to the synthesis of nicotinic acid (vitamin B3) by the body, as well as a precursor of the neurotransmitter serotonin.
Many studies have shown that tryptophan is beneficial for weight loss because it is able to influence the choice of food, reducing the desire to eat sweet foods and encouraging the consumption of protein nutrients.
The assimilation of tryptophan in the brain is facilitated by the presence of vitamin B6 and vitamin C. Some researchers have noted that in the period in which both animals and men are fed with diets deficient in the amino acid tryptophan, their appetite grows symptomatically.

l tryptophan is present in protein foods with eggs, nuts, meat and milk. The synthesis and cleavage of tryptophan and its conversion into serotonin requires nutrients such as vitamin B6, vitamin PP and glutathione. A diet deficient in tryptophan induces low levels of serotonin in the brain.
With this limitation the brain diffuses the signals characteristic of the fast, triggering appetite regulatory centers in order to push food intake and carbohydrates in particular.

This is caused by two reasons: first, a high-carbohydrate diet is a quick source of energy for the body. In addition a diet with high levels of carbohydrates and low protein content, increases the amount of tryptophan that reaches the brain through the blood-brain barrier.

More tryptophan reaches the brain and more serotonin will be generated, and the signals to the appetite regulatory centers will become stronger, so will stop the demand for food, at least momentarily.
A consequence of the low levels of serotonin is the carbohydrate craving and a significant carbohydrate intake leads to obesity. These “cravings” (compulsive search for particular foods or instinctive) are also the main signals of bulimia.

Tryptophan has the same consequences of a meal based on carbohydrates, given that supports the release of the neurotransmitter serotonin in the brain and this would clarify the least desire for foods based on carbohydrates accompanying its suministracion.
The incessant mania of snacks rich in carbohydrates, often associated to a considerable demand for food characteristic of people with the problem of disproportionate weight, can be induced by an irregularity in the process of production of serotonin within the brain, which can be controlled from tryptophan.

How does Humor against nervous hunger

The Escolzia makes you sleep better without be dazed, decrease the period of falling asleep and reduces the frequency and duration of nocturnal awakenings. This herb has provided evidence of validity in the lightweight than in the insomnia of moderate severity.
They are also important further property of escolzia and in particular that the one antidepressant and analgesicso much that the escolzia is usually used also against headaches. Some recent studies conducted in California indicate that the main action of the Escolzia would show the responsibility of the Central Nervous System. The phytocomplex would exhibit a certain activity on the smooth muscle.

Chamomile has anti-spasmodic and calming properties and is very effective to hold the muscle contractions of the stomach and intestines caused by tension and anxiety. Chamomile is also suitable for the treatment of any type of colic, especially those of the kidney and gallstones to its outcome decidedly pain-relieving and soothing.

In the Chamomile there is an active principle called azulene which has the particularity to inhibit the formation of histamine and adjust the effect of serotonin which is a neurotransmitter with multiple activities.
The incapacitation to sleep can be caused by a insufficiency of serotonin. Chamomile has been inserted in the formula of Humor in order to optimize the activity of serotonin.

The Hawthorn is rich in flavonoids, amines, sterols, coumarins, choline and vitamin C. It is suitable for disorders of the heart, especially if related to anxiety-inducing ambit making it therefore appropriate in the case of impaired cardiac function in the senile heart disease who do not require the use of digitalis, palpitations related to anxiety and hypertension but also in case of insomnia and anxiety.
This plant is an indirect anxiolytic because it helps to deal with good results cardiovascular symptoms of anxiety, rather than having a specific anxiolytic action on neural circuits.

The studies reveal that the main activity of the hawthorn is accomplished at the level of the cardiovascular system, with an effective improvement of endurance to fatigue.
The phytocomplex exerts its action on beta-adrenergic receptors (such as partial agonist) and by inhibition of the phosphodiesterases, which follows an increase in the rate of intracellular cyclic AMP (Cyclic AMP (cAMP) is a second messenger, namely a soluble molecule, cytosolic, produced by an enzyme called ADENYLATE CYCLASE) connected, in turn, to an increase of free calcium ions.

How does Humor against nervous hunger

It has been proven that such results are no doubt related to 'action of oligomeric procyanidins and flavonoids such as vitexin (and its ramnoside). It still remains to be documented the contribution of pentacyclic triterpenes. The

main activities provided by the Hawthorn are:

  • The increase in the force of contraction of the heart muscle due to flavonoids and procyanidins
  • Antiarrhythmic effect mainly due to flavonoids
  • Increase in coronary blood flow due to the flavonoids and procyanidins
  • Peripheral vasodilatation mainly due to procyanidins
  • Sedative action on the central nervous system.

St. John’s Wort for depression work with different synergistic activities:

  • Inhibition of monoamine oxidase type A (MAO-A) and catechol-methyl-transferase. These activities result in an increased activity of the mediators with nervous activity neurotonic. Both behaviors are due to the quercetin aglycone and its the tetraidroxantone that generate a highlighted antidepressant effect
  • Inhibition of the reuptake of serotonin, norepinephrine and GABA at the synaptic level (?-aminobutyric acid is the main inhibitory neurotransmitter in the central nervous system).
    It has been documented that the increased stability of these mediators at the synaptic level, activates an intense antidepressant activity. The hypericin may also resettle on serotonin receptors located on nerve cells, acting also as an antidepressant
  • In the hormonal effects where you encounter an particular increase in the nocturnal secretion of melatonin, this event facilitates restful sleep and a good awakening without hindering REM sleep (from Rapid Eyes Movements) whom occur during the elaboration and mnemonic learning of the events of the day
  • Modulation of cytokine release: hypericum extract limits the production of interleukin-6, which can ease the release of corticotropin hormone, often connected to depressive manifestations
  • Outcome calming and relaxation of the nervous tension due to the intervention of bioflavonoids, hyperforin, procyanidins.