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you are visiting: home » products » Wonderup » composition » soy (Pag. 1) » (Pag. 8)
Soy - Pag. 8


Soy: natural ingredient of Wonderup

Some articles about the health benefits of soy isoflavones in the treatment of menopausal problems
The Cancer Killer - A hormone in the soy kills cancer cells
[Cancer killer - A hormone in soya beans starves tumour cells to death] New Scientist 14 mar 98

Biochemists in the United States have identified as a key ingredient in the soybeans annihilate cancer. They have demonstrated that genistein, a plant estrogen, plays a key role in suppressing the growth of cancer cells. Asian diets high in soy have been linked with low incidence of cancers, particularly breast, colon and prostate.
This link has been reinforced by evidence that when Asians migrate to the U.S. and abandon the diet rich in soy, their risk of developing these cancers increases.

Amy Lee of the University of Southern California in Los Angeles discovered that genistein is a key factor in this. It works by weakening the cancer cells' response to the stresses that usually impel them to grow faster. “When a cancer cell grows at full blast, the cells soon run out of oxygen and glucose that are normally provided by blood”, says Lee. To compensate, they send out a chemical SOS that triggers the formation of new vessels to nourish the tumor, a process called angiogenesis.

Soybeans, useful element to combat stressIn previous experiments on tissue cultures, Lee and others have shown that genistein can blunt the response of cancer cells to stress. Now, they know the exact mechanism. She and her colleague Yanhong Zhou have demonstrated that genistein blocks the action of a transcription factor known as the CCAAT binding factor. This protein normally binds to a “reason” in the important genetic DNA and triggers the stress genes. Genistein adds phosphorous to the binding factor, neutralizing it before it is activated, so that cancer cells die because deprived of their nutrition (the Journal of the National Cancer Institute, Vol 90, p 381).
“These tests are preliminary, but genistein really stands out as the ingredient that is more active in stopping cancer growth and angiogenesis”, says Lee. Crucially, the researchers found that genistein has no effect on normal, healthy cells that does not are rapidly dividing cells such as cancer. “It don’t blocks the normal synthesis of this protein in healthy cells”, says Lee (Andy Coghlan).

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