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you are visiting: home » products » Wonderup » composition » soy (Pag. 1) » (Pag. 6)
Soy - Pag. 6


Soy: natural ingredient of Wonderup

Some articles about the health benefits of soy isoflavones in the treatment of menopausal problems
Soy phytoestrogens: an alternative approach to traditional hormone therapy for menopause?
[Phytoestrogens of Soybeans: An Alternative Approach to Traditional HRT?] - Presented at “Symposium on the health impact of soy protein” - Center for Human Nutrition at UCLA (University of California), January 20, 1998 by Thomas B. Clarkson, D.V.M. Professor of Comparative Medicine, School of Medicine of Wake Forest University

The traditional therapy for postmenopausal hormone replacement therapy (HRT) preserves bone density, reduces the risk of coronary heart disease and can support cognitive function with advancing age. Despite these health benefits, the use of HRT is low (about 10% of women over 55 years). This is related primarily to fear of breast cancer and the need of a side-effect of progestin administration.

We focused on the phytoestrogens (genistein and daidzein) from soybeans as potential alternatives to traditional HRT - particularly - because they can be protective against breast cancer and anti-estrogens for the endometrium thus obviating the need for a progestin.

Cardioprotective effects

We compared the soy phytoestrogens and conjugated equine estrogens administered to surgically postmenopau-
sal monkeys with their effects on concentrations of plasma lipoproteins. SBEs increased HDL cholesterol and Apo A1 more than conjugated equine estrogen, and LDL cholesterol was decreased more by SBEs. Conjugated equine estrogens, but not the SBEs, resulted in hypertriglyceride-
mia. Data on atherosclerosis of postmenopausal female monkeys are incomplete but both soy phytoestrogens and conjugated equine estrogens inhibit progression of athero-
sclerosis. Soy phytoestrogens, like estradiol, allow the coronary arteries to dilate in response to acetylcholine.

Effects on the breast and endometrium

We compared the effects of soy phytoestrogens and conjugated equine estrogens on breast and uterus of postmenopausal monkeys. Soy phytoestrogens are not estrogen agonists for the breast or the endometrium, estrogens are also antagonists at these sites, preventing the usual proliferative changes induced by estradiol.

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