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Soy - Pag. 7


Soy: natural ingredient of WonderOver

Effects on the brain

The effect of soy phytoestrogens on brain biomarkers of cognitive (brain derived neurotrophic factor and acetylcholine production) are comparable to those of estradiol (UCLA Center for Human Nutrition 900 Veteran Avenue Los Angeles, CA 90095-174).

Soy Protein Isoflavone Effects on Breast Tissue

Presented at the “Symposium on the impact on the health of soy protein” - Center for Human Nutrition at UCLA (University of California) January 20, 1998 by Stephen Barnes, Ph.D. Professor of Pharmacology and Toxicology and Biochemi-
stry and Molecular Genetics to the School of Medicine at the University of Alabama at Birmingham.

The isoflavones, so abundant in soy, have been proven to have biochemical and biological effects in a series of in vitro and animal models. These effects are not only based on the estrogenic properties of isoflavones, but also their role as inhibitors of protein tyrosine kinase, regulators of gene transcription, modulators of membrane transporters and as antioxidants.

Predicting the outcome of the effects of isoflavone-rich diets, such as those based on soy, on chronic diseases (cancer and heart disease) should not be based on only one of these mechanisms. For example, the prevention of osteoporosis by isoflavones (an estrogenic effect) is in contrast with epidemiological and laboratory data that suggest that soy and isoflavones prevent cancer.

However, the recent discovery of a new estrogen receptor (ERP) which selectively binds the isoflavone genistein provides new arguments to explain the paradox of estrogen. the ERP shows a possible distribution of tissue different from the classical estrogen receptors, being abundant in bones, brain, cardiovascular system, the genitourinary system, lungs and prostate, but not in the breast.

Thus isoflavones may be naturally occurring forms of an important new class of drugs called selective estrogen receptor modulators, currently in development for the treatment of the disease in postmenopausal women (UCLA Center for Human Nutrition 900 Veteran Avenue Los Angeles, CA 90095 More Abstracts - 1742 © Copyright 1998 Indiana Soybean Board).

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