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you are visiting: home » products » WonderOver » composition » soy (Pag. 1) » soy (Pag. 6)
Soy - Pag. 6


Soy: natural ingredient of WonderOver

Soy phytoestrogens: an alternative approach to traditional hormone therapy for menopause?

[Phytoestrogens of Soybeans: An Alternative Approach to Traditional HRT?] - Presented at the “Symposium on the impact on the health of soy protein” - Center for Human Nutrition at UCLA (University of California) January 20, 1998 by Thomas B. Clarkson, D.V.M. Professor of Comparative Medicine at the School of Medicine of Wake Forest Universi-

The traditional therapy of postmenopausal hormone repla-
cement (HRT) preserves bone density, reduces the risk of coronary heart disease and can sustain cognitive function with the age. Despite these beneficial health effects the use of HRT is low (about 10% of women over 55 years old). This is related primarily to fear of breast cancer and the need for a collateral suministración of progestin.

We focused on the phytoestrogens (genistein and daidzein) from soybeans as potential alternatives to traditional HRT - especially - because they may be protective against breast cancer and are antiestrogens for the endometrium thus obviating the need for a progestin.

Cardioprotective effects

We compared the soy phytoestrogens and conjugated equine estrogens administered to surgically postmenopau-
sal monkeys with their effects on concentrations of plasma lipoproteins. Soy phytoestrogens increased HDL cholesterol and Apo A1 more than conjugated equine estrogens, and LDL cholesterol was decreased more by soybeans.

Conjugated equine estrogen, but not soy phytoestrogens, resulted in hypertriglyceridemia. Data on atherosclerosis in postmenopausal female monkeys are incomplete but both phytoestrogens that conjugated equine estrogens inhibit progression of atherosclerosis. Soy phytoestrogens, such as estradiol, enable the coronary arteries to dilate in response to acetylcholine.

Effects on breast and on endometrium

We compared the effects of soy phytoestrogens and conju-
gated equine estrogens on breast and uterus in postmeno-
pausal monkeys. Soy phytoestrogens are not estrogen agonist for either breast or to the endometrium; also have estrogen antagonist at these organs preventing the usual proliferative changes induced by estradiol.

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