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Hawthorn: natural ingredient of WonderOver

The essential activity of Hawthorn (Crataegus oxyacantha) is at the level of the cardiovascular system with a proven improvement of enduran-
ce to fatigue. Carries out an andrenergicic action on the beta receptors (such as partial agonist). They are “switches” located on the cell membrane.

At this receptor bind two neurotransmitters, adrenaline and noradrenaline, by inhibition of phosphodiesterase (substan-
ce that accelerates a particular chemical reaction), which follows an increase in the rate of intracellular cyclic AMP (cyclic AMP (cyclic adenosine monophosphate) or cAMP is a metabolite of the cells produced by the enzyme adenylate cyclase from ATP).

It is an important “second messenger” involved in the mechanisms of signal transduction to the interior of the living cells in response to various stimuli such as those induced by hormones glucagon or adrenaline, which are not able to cross the cell membrane.
Its main function consists in the activation of the protein kinase to regulate the passage of calcium through transmembrane ion channels linked in turn to an increase of free calcium ions. It has been well demonstrated a sedative action on the central nervous system.

The anxiolytic and muscle relaxant action of the hawthorn (Crataegus oxycantha L.) is found with a determinate behavior on the excitability of the nervous system. The active ingredients in the plant insomnia diminish the sense of anxiety and dizziness.
Hawthorn is well accepted by the body and does not show any secondary outcome. It is rich in flavonoids, which are about 2% of the weight of dry vegetable and proantocianidoli 3% of the weight of the dry plant. This shrub has a strong affinity towards the heart, especially due to flavonoids and proantocianidoli.

This finding seems to have to be attributed especially to the tannins and flavonoids in force in this plant since it has been proven that these procure sedation and increase sleep.
Decidedly important is the possibility that the hawthorn has to block the free radicals. Thanks to its action, the oxidation of LDL, which are the particles of cholesterol that are usual placed in the wall of blood vessels following their oxidation, is greatly diminished.

Hawthorn belongs to the rose family of which are used the flowering tops and leaves. The active ingredients are mainly flavonoids (iperosid, vitexin-2”-ramnosid), glycosyl flavones, procyanidins, pentacyclic triterpenes (ursolic acid, crategolic acid, oleanolic acid, acantolic acid, neo tegolic acid). The title of flavonoids percentage of drugs should be 0.7% at least.

WonderOver: Composition (Hawthorn) »
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