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you are visiting: home » products » Humor » composition » st. john’s wort (Pag. 1) » st. john’s wort (Pag. 2)
St. John’s W. (Pag. 2)


St. John’s Wort: natural ingredient of Humor

Clinical uses (continued ...)

The mechanism of action of Hypericum perforatum is to inhibition of the reuptake of serotonin in the post-synaptic inhibition of the uptake of norepinephrine and dopamine and binding (in vitro) with the GABA receptor (GABA is amino butyric acid of gama and is an inhibitory neurotransmitter).

St. John’s Wort: natural ingredient of HumorAt therapeutic doses there is no inhibition of MAO (inhibitors Mono-Amino-Oxidase, raise the levels of serotonin, norepinephrine and dopamine by inhibiting the mono-amino-oxidase enzymes that reduce, through a process of oxi-
dation, the concentration blood of these neurotransmitters), even if the hypericin inhibits the in vitro.

It is reported by some authors a certain hypotensive action. Not recommended for use during pregnancy, in the absence of specific studies. Are possible photosensitivity reactions and interference with antiretroviral drugs for HIV.
St. John’s Wort can interfere with the metabolism of carbamazepine, quinidine, calciantagonisti, losartan, stero-
ids, tamoxifen, taxol, digoxin, theophylline, cliclosporina, progestogens, warfarin, fenitorina, tolbutamide, digoxin.

Hormonal effects

In particular, it determines a discrete increase in the production nocturnal melatonin. This action promotes restful sleep and a best awakening without disturbing the sleep REM (rapid eye movement is the “rapid eye movement” that takes place during a stage of sleep during which occurs the reprocessing and storage of the events of the day).

Modulation of cytokine release

The hypericum extract reduces the formation of interleukin-6 capable of sustaining the release of corticotropin, reason often connected to depressive manifestations. Result calming and relaxation nervous anxiety made in relation to the action of bioflavonoids, hyperforin, procyanidins.

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