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you are visiting: home » products » Humor » composition » st. john’s wort (Pag. 1)
St. John’s W. (Pag. 1)


St. John’s Wort: natural ingredient of Humor

St. John’s Wort: natural ingredient of HumorSt. John’s Wort acts synergistically on depression using different methods such as blocking monoamine oxidase type A (MAO-A) and catechol - methyl-
transferase (COMT), which implies an increased activity of the nervous mediators stimulating action. Both of these actions are due to quercetin, its aglycone altetraidroxantone producing a marked antidepressant effect.

St. John’s Wort (Hypericum perforatum) may act against premature ejaculation due to the possibility that the active ingredients have to inhibit the reuptake of serotonin, norepi-
nephrine, and GABA at the synaptic level.
There is also evidence that the prolonged presence of these mediators at the synaptic level is expressed with a strong antidepressant activity. Hypericin may also settle in the serotonin receptor sites on nerve nuclei in his role, even in this situation, of antidepressant.

Hypericum perforatum L. is an herb which is used the flowering tops, it is equipped with antidepressant and mood stabilizer. The active compounds are derived from naftody-
antronics said “hypericins” which include hypericin, the pse-
udohypericin, the cycle-pseudo-hypericin, the iso-hypericin, the proto-hypericin.
There are also flavonoid glycosides, biflavons, procyanidins felilpropani (in small quantities), acyl-flora glucianoli, hyper-

Clinical uses

St. John’s Wort: natural ingredient of HumorThe antidepressant action of hyperi-
cum has been confirmed by several tests with both placebo that by comparison with antidepressants known as sertraline, fluoxetine and the laparoxetina.
The results were so encouraging that in Germany, St. John’s wort has been approved by pharmacopoeias as a method of treatment of anxiety and depression.

The efficacy of hypericum is compa-
rable to that of imipramine emaproti-
lina. It was carried out a meta-analy-
sis of 23 randomized trials with hypericum involving a total of 1757 patients with mild to moderate depression.
The conclusion was that the hypericum extract, evaluated after 2 to 4 weeks, is superior to placebo and as effective as antidepressants classics.

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