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you are visiting: home » products » Zetastop » composition » licorice (Pag.1) » licorice (Pag. 3)
Licorice - Pag. 3


Licorice: natural ingredient of Zetastop

The most important mechanism of action of licorice is to block the hepatic redattase of corticosteroids and a direct stimulus of the production of adrenal hormones. Recently it has been demonstrated action at receptor level for the Gluco and mineral corticoids. In detail:

  • Anti-inflammatory action: Numerous studies have confirmed the anti-inflammatory activity of licorice, probably due to the strengthening of indirect glucocorticoid. In an animal study, GA has been shown to possess anti-arthritic activity similar to that of cortisol
  • Antiulcer action: the antiulcer activity has been studied mainly on the carbenoxolone (CB) that is chemically and pharmacologically similar to GL. CB improves the protective properties of the gastric mucosa, probably through a mediation of prostaglandins, production of secretin, or through a direct action on the mucosa the same. The fact that the de glicirrizinata licorice (DGL) has also demonstrated an anti-ulcer activities posed the problem of identifying the responsible principles. It should be clarified, however, that the DGL is not completely free of GL, but it contains less than 3%, and has a high content of flavonoids, molecules often at high antioxidant activity and anti-inflammatory
  • Action at the pulmonary level: the expectorant activities of licorice seems to be attributable at least in part to the GL
  • Antispasmodic action: at the gastrointestinal level
  • Action on the immune system: GL acts on the hepatitis B virus and hepatitis A (in this case, preventing the virus from penetrating the cell); while the GA has shown, in two studies in vitro to inhibit the growth and plant pathology of various DNA and RNA viruses
  • Hepatoprotective action: GA inhibits chemically induced liver damage by preventing the damage from free radicals and preventing the formation of the same, with the reduction of transaminases and the accumulation of triglycerides. Transaminases are enzymes that indicate liver cell damage, while the alteration of serum lipids and lipoproteins are a sensitive index but nonspecific liver disease. An acute liver disease is frequently associated with increased plasma levels of triglycerides
  • Estrogenic activity: it seems that licorice has a behavior "amphoteric" compared to estrogen metabolism, that inhibits the effects of estrogen when levels are elevated in circulation and strengthens them when levels are low
  • Diuretic activity: the asparagine is a strong diuretic
  • Antibacterial action: the isoflavones are antimicrobial in vitro (SAPH. Aureus, Strept. Mutans, Candida albicans)
  • Antiallergic action: inhibition of histamine release.
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