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you are visiting: home » products » Zetastop » composition » licorice (Pag.1) » licorice (Pag. 2)
Licorice - Pag. 2

Zetastop:

Licorice: natural ingredient of Zetastop

Constituents and chemical formula of the licorice
  • Triterpenic glycosides (saponins, triterpenoids penta cyclic): mainly glycyrrhizin (GL-synonyms: glycyrrhizic acid and acid glycirrizinic), present as salts of K and Ca [6- 14%], hydrolyzed by the intestinal flora to glucuronic acid and glycyrrhetinic acid (GA- synonym: glicirritic acid). The GL is responsible for the sweetness of licorice, being 50 times sweeter than sucrose. There are also 13 other saponins lower
  • Flavonoids and isoflavonoids (1%)
  • Phytosterols: b-sitosterol and stigmasterol
  • Coumarins
  • Polysaccharides, especially Lucan
  • Amines and amino acids
  • Other constituents: bitter principles (glyciramarine), starch (about 20%), asparagine (1-2%), sugar (15%), gum, lignin, triterpenes and essential oils, licofuranone, stilbenes, tannins, wax.
The active ingredient most important of the licorice: glycyrrhizin

Glycyrrhizin (formula: C 42H62O16; molecular weight: 822.94) is a triterpene glucoside whose triterpenic skeleton is formed by glycyrrhetinic acid, which is not sweet, and to which are linked two residues of iduronic acid.
It can be called either glycirrizinic acid, glycyrrhizic acid, glycyrrhetinic glycosyl acid. The content of glycyrrhizin in the root varies from 2 to 4% depending on the growth conditions of the plant. Glycyrrhizin is a partially hydrolyzed by glucuronidase in the corresponding aglycone, the glycyrrhetinic acid.

The history of modern research on the mechanisms of action of licorice begins in 1946The history of modern research on the mechanisms of action of licorice begins in 1946, when the Dutch chemist Revers observed that his patients, sick stomach, noticed significant improvement with the use of a preparation of licorice.
Revers also noted that, at therapeutic doses, patients had edema of the face and limbs. Thanks to the studies that followed, GL and GA were identified as the compounds responsible both of antiulcer that the edematogen, and it was discovered their strong anti-inflammatory activity. Carbenoxolone, the anti-ulcer medication most important of the 60's, was nothing more than a synthetic version (more absorbable) of GA; but also caused side effects edematogen of the Licorice.

The glicirizzina, after ingestion, is converted by the bacterial flora (Clostridium innocuum, Ruminococcus spp., Eubacterium spp.). Prior to acid 18-ß-glycyrrhetinic acid and then to 3-epi-18-ß-glycyrrhetinic acid, which is the form in which the molecule is actually absorbed (apart from a negligible amount of unmetabolized GL).

Concept by Webattuale
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