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you are visiting: home » products » Humor » against anxiety and depression » composition » st. john’s wort (Pag. 1) » st. john’s wort (Pag. 3)
St. John’s W. - Pag. 3


St. John’s Wort: natural ingredient of Humor

Pharmacological activities (To be continued ...)

The hyperoside (quercetin-3-galactoside) is however not characteristic of hypericum but it can also be found in different plants which are part of other families, such as the Ericaceae. The dimeric flavonoids are those who favor the yellow color of the flowers, while hypericin attributes the particular staking from red petals to stamens and the edge of the leaves.

Has been also noted a significant content in catechinic tannins (proanthocyanidins), particularly in flowers; substan-
ces which, however, are subject to very substantial fluctuations during the course of vegetation. The titration recognized of the extract reported by the German Pharmaco-
poeia is in total hypericin, for which is acknowledged the combination of 1.8 antranoli dimers, polycyclic components at different levels and forms of substitution: depending on the substitution pattern, thus giving origin to pseudohyperi-
cin, respectively, to ’hypericin, to the isoproto and protopseudo-hypericin.

The combination corresponding to each of them in the whole plant, stems from its origin. Studies have been conducted which give evidence of the mutability percentage related to hypericin in accordance the place in the European or Asian origin of the grass. This proves the value of the titration of the extract for ensuring the homogeneity of the pharmacological activity.

Hypericin, currently, despite not being rated as more important in the process of action of hypericin molecule remains relevant to the assay of ’extract. The pattern of action of hypericum is still subject of research and discussion. There are several current theories among which the most plausible argues that hypericum put in place multiple modes of action at the same time.

St. John’s Wort seems capable of increasing serum levels of serotonin, similarly to certain antidepressant medications. The complexity of the method of action of the extract, also determines a weak interdiction of the ’activity of the protein compounds MAO-A and MAO-B, a relevance for GABA receptors and the serotonin reuptake stop that, almost certainly, is the fundamental device of the antidepressant St. John’s wort and is also the neurotransmitter that regulates mood, with consequential increase of the outcomes related to the amount of serotonin usable.

In addition to this, several tests have proved that the extract of hypericum limits the reabsorption of two other neuro receptors called noradrenaline and dopamine that they also possess an important role in depression. St. John’s Wort is considered an important tonic, capable of consolidating the sensory reactivity of the individual and to appear as an important rebalancing of mood.

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