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you are visiting: home » products » Evergreen » composition » glucosamine (Pag. 1) » glucosamine (Pag. 4)
Glucosamine - Pag. 4


Glucosamine: ingredient of Evergreen

Chondoprotective Agents: Chondroitin Sulphate

Basic structure of Chondroitin Sulphate-6As already indicated, is the glycosaminogly-
can that is active in a quantity more relevant to the interior of the cartilages. It is a polymer of glucuronic acid and N-acetyl-galactosamine sulfate which can is reveal in multiple tissues, among which there are the tendons, intervertebral discs, the bones, the cornea and the heart valves.

Its major job in relation with the cartilage is to give shape to the links with the collagen fibrils. It was also substantiated an inhibitor result in respect of enzymes (collagenase and elastase) active in the synovial fluid and that has caused regression of the cartilage.
Over the years the production of chondroitin sulfate by chondrocytes decreases, with the consequence of having a cartilage increasingly weakened.

Glucosamine: synergistic effects of glucosamine and chondroitin sulfateAssume chondroitin sulfate in the case of osteoarthritis can facilitate the increa-
se of the glycosaminoglycans concentra-
tion in cartilage and limiting its excessive degradation.
The dose absorbed following oral intake was quantified to be approximately 20% of the total. Even in this circumstance, was not seen no harm or harmful side outcomes.

Many studies recently disclosed have reported that after oral administration of this drug, patients have noticed a decrease in pain (mild anti-inflammatory activity), with a consequent decrease in ’use of anti-inflammatory drugs or other analge-

Synergistic effect

Both the glucosamine that the chondroitin sulphate, evaluated separately, do not enjoy all three peculiarities of a condoprotettore, while this is found if their effects are additi-
ve. In summary:

  • Glucosamine: stimulates the metabolism of chondrocy-
    tes and proteoglycans
  • Chondroitin sulfate: it inhibits enzymes that break down cartilage

Since the Glucosamine promotes the formation of new cartilage and the chondroitin sulfate slows the degradation, the result that follows after a combined administration for periods during the gradual disability, will be the limitation of the osteoarthritis development.

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