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you are visiting: home » products » Evergreen » composition » glucosamine (Pag. 1)
Glucosamine - Pag. 1


Glucosamine: ingredient of Evergreen

Osteoarthritis (OA) is the most common form of joint disor-
der afflicting the world’s population, changing significantly the quality of life. It has been noted recently, an increase of attention to the use of chondroprotective methods for the treatment of OA. To better understand the function of these substances, it’s necessary to know the structure of cartilage.

The cartilage: particular form of a ligament in good health

Glucosamine: ingredient of EvergreenIn a normal condition of healthy, the articulation of the bones are cove-
red by cartilage and surrounded by synovial fluid. In a healthy joint, the cartilage is smooth and the synovi-
al fluid provides a proper lubricati-
Normally the cartilage is composed of 2% of cells, called chondrocytes, 20 - 40% from the extracellular matrix and from 60 - 80% of water. The chondrocytes form and retain the matrix which, in turn, plays a habitat conducive to the development of these cells.

The extracellular matrix is composed to 60% of collagen (predominantly type II collagen) and from 40% of proteogly-
cans which in turn are composed of glycosaminoglycans (or mucopolysaccharides) linked to a protein chain. The most significant glycosaminoglycans are chondroitin-6 sulfate, chondroitin sulfate-4, Keratan Sulfate and Dermatan Sulfate. In the matrix the proteoglycans are connected to molecules of hyaluronic acid so as to make particular aggregates in the form of feather. These aggregates are very hydrophilic, this illustrates the considerable volume of water present in the matrix. The proteoglycans are connected in parallel to the collagen fibrils, with the task to circumscribe the water in excess that can totally alter the physical characteristics of the cartilage.

Structure of cartilage

Structure of cartilageLike all other connective tissu-
es of the human body, also the articular cartilage is a living substance that is dynamic and continually worn and replaced.
In healthy individuals, applies a proportion between the breakup of the old fabric (through the synthesis of organic substances by the chondrocytes) and the recomposition of a new one.

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