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you are visiting: home » products » E > Micra » composition » willow (Pag. 1)
Willow - Pag. 1

E > Micra:

Willow: natural ingredient of E > Micra

Willow: natural ingredient of E > MicraThe bark of the willow tree (Salix alba) and its derivatives are used as anti-inflammatory, antirheumatic, antipyretic, anti headache, particularly because they inhibit the cyclooxygenase and the consequential prostaglandin synthesis responsible for fever, pain and inflammation.

Today’s phytotherapy allows us to take advantage of scientifically dried extracts of willow bark with a defined quantity and repeated in active principles (salicin). This is the only way to obtain an actual response to therapy without encountering risks.

The dosage indicated may change depending on the disease to treat and to the need of the individual user but it is essential to refer to the concentration of the extract; usually enough to take a dose equal to 60-120 mg. salicin per day.

Contrary to acetylsalicylic acid, the extract of willow is usually better endured at the gastric level because glucosides operate to the way of a structure of the active ingredient to slow release, which is then released and put in action, by hydrolysis and oxidation, only after absorption from enteric.

Polyphenols, which are also present in the extract, exert surely an asset protectress on the mucosa.
To better understand the mechanism of action of the willow is good to have this component in the context of medicinal plants containing glycosides. They are numerous and belong to different categories and varieties.

Willow possesses analgesic activity medications, antipyretic and antirheumatic. Regarding drug interactions, it is hypothesized alteration in the kinetics of some drugs, although in the current scientific literature are not put in evidence reliable data, it may be important the action combined with certain categories of sedatives.

salicylic acid and salicylates mechanism of action

The salicylic block the biosynthesis of prostaglandins (PG), prostacyclin and thromboxane (TXA) by stopping the enzyme prostaglandin H synthase (PGHS). This compound is represented by two protein isoforms (In biochemistry, it defines isoform protein or, more commonly, an isoform the versions of a same protein), known as COX-1 e COX-2.

The COX-1 are present in many types of cells, including platelets, which are responsible for immediate responses such as renal homeostasis, gastric and vascular. Their arrest in platelet level, appears to be inconvertible, so it generates the block in the biosynthesis of TXA (substance pro aggregating and vasoconstrictor).

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